Name: Riboclub: Teleconference
Start: 2024-12-2T12:00-5:00
End: 2024-12-2T13:30-5:00

december 2024

02dec12 h 00 min13 h 30 minRiboclub: Teleconference

Event Details

The next Riboclub teleconference will be from 12:00 to 13:30 and will feature the following talks:

It can be accessed at: https://home.riboclub.org/seminars/#next

2024-2025 – December Monthly session

Elizabeth Trofimenkoff, Ph.D. student

Marc Roussel lab – University of Lethbridge (Canada)

Mathematical modeling of eIF5B-mediated non-canonical translation initiation as a chemotherapeutic target

Under hypoxic conditions, which is observed in cancer cells, cap-dependent translation initiation is disrupted via the phosphorylation of eukaryotic initiation factor 2- (eIF2). However, cancer cells can exploit a non-canonical pathway that replaces eIF2 with eIF5B for initiator tRNA delivery to the ribosome, resulting in the synthesis of antiapoptotic proteins such as XIAP. Mathematical models were derived and used to identify several potential therapeutic targets in this non-canonical mechanism.

Credo Casmil, Ph.D. student

Anna Blakney lab – University of British Columbia (Canada)

Expanding the repertoire of self-amplifying RNA vectors: an emerging frontier in mRNA vaccines for infectious diseases

Self-amplifying RNA (saRNA) results in prolonged and higher expression of encoded gene compared to standard mRNA. We designed saRNA vectors from alphaviruses. We showed that by tuning the vector design, we modulate the magnitude and duration of protein expression ex vivo and in vivo and influence the humoral and cellular immunity generated by saRNA vaccines using COVID-19 as a model system.

Indu Negi, postdoc fellow

Stacey Wetmore lab – University of Lethbridge (Canada)

Tuning the ykkC-I riboswitch: insights into potential effects of metal ion-induced allostery through MD simulations

Riboswitches exhibit high ligand specificity and potential as drug targets. This study focuses on ykkC (guanidine-I) riboswitches, the sole receptors for guanidinium cations, using long-timescale molecular dynamics simulations. Key findings reveal how guanidinium ions and metal cations drive structural transitions, modulate ligand-binding dynamics, and influence RNA regulation. These offer insights into RNA-based regulation and potential applications in drug discovery and biosensing.

Monday December 2, 2024 – 12 PM (EST)

Online: https://us02web.zoom.us/j/84699021920?pwd=V1lTRlF1R2RDSjZEdXZsd0FPaVBxUT09 Presential: Building Z8 – Room 1049/1050 (Sherbrooke)

December 2024 Monthly Session (1)

Time

(Monday) 12 h 00 min - 13 h 30 min

Calendar GoogleCal

04dec16 h 00 min18 h 00 minRNA Collaborative Seminar Series

january 2025

05janAll Day10Gordon Research Conference: RNA Nanotechnology

13jan12 h 00 min13 h 30 minRiboclub: Teleconference

27janAll Day30Keystone Symposia: Non-Coding RNA Biology: New Roles and Diversity

february 2025

04feb12 h 00 min13 h 30 minRiboclub: Teleconference

23febAll Day28Gordon Research Conference: Molecular Insights into Protein Synthesis in Health and Disease

Event Details

The Translation Machinery in Health and Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The Translation Machinery in Health and Disease GRC will highlight new molecular insights into translation including control during normal processes and how their dysregulation contributes to a wide array of diseases. Global and specialized translation will be discussed in the context of neurological disorders, cancer, pathogens and immunity, stress and aging, cellular condensates, mitochondria, ribosomopathies and rare diseases as well as the latest conceptual and technical advances that drive new discoveries in translation.

https://www.grc.org/translation-machinery-in-health-and-disease-conference/2025/

Time

february 23 (Sunday) - 28 (Friday)

Calendar GoogleCal

march 2025

06marAll Day08The Center for RNA Biomedicine & Society for RNA Therapeutics: 9th RNA Symposium

10mar12 h 00 min13 h 30 minRiboclub: Teleconference

16marAll Day21Gordon Research Conference: Biological Mechanisms and Applications of RNA Editing and Modifications

Event Details

Biological Mechanisms and Applications of RNA Editing and Modifications

March 16 – 21, 2025

Chairs: Joshua J C Rosenthal and Ute Kothe

Vice Chairs: Kristin S. Koutmou and Mark Helm

The RNA Editing GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The GRC on RNA Editing is the only international meeting dedicated exclusively to RNA editing and RNA modifications. The 2025 meeting is subtitled “Biological Mechanisms and Applications of RNA Editing and Modification” and will showcase the breadth of the newest advancements in this rapidly growing field. RNA editing and modification are highly abundant phenomena, occurring in almost all RNAs, in all cells, and in all organisms. These relatively simple molecular events carry far-reaching biological consequences, and our knowledge about them is expanding quickly. Importantly, many biological roles of RNA editing and modification are actively being uncovered, and these range from the control of gene expression, adaptation to stress, viral, microbial and parasitic infectivity, organismal development, brain function, innate and adaptive immunity, inherited diseases, cancer and more. Based on a strong foundation in mechanistic and functional investigations on RNA editing and modification enzymes, our research field has now entered a new and exciting era where a variety of applications are emerging that utilize RNA editing and modifications as tools for research and health. The 2025 meeting will showcase these novel applications in the areas of therapeutics that alter the transcriptome and proteome, more effective mRNA vaccines, among others. A goal of this meeting is to facilitate the translation of academic discoveries in the area of RNA editing and modification into platforms that advance biotechnology and health. Overall, the 2025 GRC on RNA Editing will accelerate discovery by inspiring research into biological mechanisms, by fostering knowledge translation, by building a strong, diverse, and inclusive community and, most importantly, by developing the next generation of creative scientists.

Link to conference website: https://www.grc.org/rna-editing-conference/2025/

Time

march 16 (Sunday) - 21 (Friday)

Calendar GoogleCal

april 2025

03aprAll Day042025 NCI RNA Biology Symposium

Event Details

The goal of the NCI RNA Biology Initiative is to establish a collaborative environment that promotes the swift exchange of information and expertise regarding the structure, function, and biological significance of RNA. Our objective is to leverage this collective knowledge to advance the development of novel diagnostics and therapies. We actively foster synergistic collaborations among NCI and NIH intramural investigators, as well as between our researchers and the broader RNA community.

The symposium offers the opportunity to learn more about the current status of RNA biology in development and disease, share research, network with leading figures in the field and discuss the use and implications of these advances for clinical applications.

Organized by the NCI RNA Biology Initiative this symposium will bring together internationally renowned experts in the field of RNA biology, with the focus on:

RNA Processing
RNA Structure and Mechanism
Non-classical RNAs
RNA Therapy

Confirmed Speakers:

Olga Anczukow, Ph.D., The Jackson Laboratory
Brenda Bass, Ph.D., University of Utah
Craig Cameron, Ph.D., University of North Carolina
Patrick Cramer, Ph.D., Max Planck Institute
Nadya Dimitrova, Ph.D., Yale University
Thomas Gonatopoulos-Pournatzis, Ph.D., Center for Cancer Research, NCI
Stacy Horner, Ph.D., Duke University
Sujatha Jagannathan, Ph.D., University of Colorado Anschutz Medical Campus
Tracy Johnson, Ph.D., University of California Los Angeles
Joshua Mendell, M.D., Ph.D., UT Southwestern Medical Center
Yunsun Nam, Ph.D., UT Southwestern Medical Center
Silvi Rouskin, Ph.D., Harvard Medical School
Peter Sarnow, Ph.D., Stanford University
Igor Ulitsky, Ph.D., Weizmann Institute
Eugene Valkov, Ph.D., Center for Cancer Research, NCI
Jorg Vogel, Ph.D., Helmholtz Centre for Infection Research
Drew Weissman, M.D., Ph.D., University of Pennsylvania
Sarah Woodson, Ph.D., Johns Hopkins University
Colin Wu, Ph.D., Center for Cancer Research, NCI
Phillip Zamore, Ph.D., University of Massachusetts Chan Medical School

We hope to see you at the 2025 RNA Biology symposium!

https://ncifrederick.cancer.gov/events/conferences/NCIRNA2025