GET IN TOUCH
Nunc ullamcorper massa enim, malesuada consectetur augue rhoncus vel. Vivamus et tristique sem. Fusce in lorem et nibh. Lorem ipsum dolor sit amet, con duo secte tue adipiscing elit, sed tinci dun tut laoreet dolore mag na aliquam erat volutpa lore.
DROP US A LINE
| Last Name | First Name | University | Department | Other Affiliations | Lab Website | Lab Research Interest | Keywords | Key Publication 1 | Key Publication 2 | Core Facilities or Technological Platforms | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| McKenna | Sean | University of Manitoba | Chemistry | sean.mckenna@umanitoba.ca | None of your business | RNA | RNA, RNA, RNA | no | no | none | ||
| Bayfield | Mark | York University | Biology | bayfield@yorku.ca | http://bayfieldlab.apps01.yorku.ca/ | Our lab studies RNA processing and RNA binding proteins, especially the La and La-related proteins and how these function in the regulation of gene expression. We also study modification and folding of tRNAs and other non-coding RNAs. | RNA processing, RNA binding proteins, La and La-related proteins, RNA modifications | https://pubmed.ncbi.nlm.nih.gov/30777481/ | https://pubmed.ncbi.nlm.nih.gov/29447394/ | |||
| Blakney | Anna | University of British Columbia | Michael Smith Labs, School of Biomedical Engineering | anna.blakney@msl.ubc.ca | blakneylab.msl.ubc.ca | The Blakney Lab is a multidisciplinary group of engineers, immunologists and molecular biologists investigating the interactions between RNA, biomaterials and the immune system to prevent and treat disease. | RNA, drug delivery, gene therapy, self-amplifying RNA, vaccines, lipid nanoparticles, immunology, messenger RNA, innate immunity | https://pubmed.ncbi.nlm.nih.gov/34418521/ | https://pubmed.ncbi.nlm.nih.gov/33352107/ | |||
| Greenblatt | Ethan | University of British Columbia | Biochemistry and Molecular Biology | ethan.greenblatt@ubc.ca | www.greenblattlab.org | My lab is interested in understanding how oocytes control and maintain gene expression from long-lived mRNAs. | Translational control, reproductive biology, autism, ribosome profiling, genomics, RNA sequencing | https://www.ncbi.nlm.nih.gov/pubmed/30115809 | https://www.ncbi.nlm.nih.gov/pubmed/31755866 | We use deep sequencing and mass spectrometry | ||
| Strong | Michael | Western University | Clinical Neurological Sciences | Robarts Research Institute | mstrong@uwo.ca | not applicable | Our focus in on understanding the mechanisms of alterations of RNA stability in amyotrophic lateral sclerosis (ALS) as it relates to perturbed disruptions in neurofilament mRNA steady state levels. This includes characterizing novel RNA binding proteins in addition to understanding the genesis of differential expression patterns of miRNAs and lncRNAs. | neurofilament; miRNA; lncRNA; Rho guanine nucleotide exchange factor (RGNEF); TDP-43; mRNA stability | doi: 10.1016/j.jmb.2020.10.029 | doi: 10.1016/j.ejcb.2018.11.001 | not applicable | |
| Jan | Eric | University of British Columbia | Biochemistry and Molecular Biology | ej@mail.ubc.ca | ubcjanlab.com | We are interested in two essential steps in the viral life cycle: viral strategies that usurp the ribosome and viral proteins that modulate the host antiviral responses and cellular pathways to promote infection. We use molecular and biochemical approaches to elucidate fundamental virus host interactions. Model viruses include dicistrovirus, enterovirus, coronavirus and flavivirus. | ribosome, RNA, virus, structure, translation, internal ribosome entry sites, therapeutic RNA | https://pubmed.ncbi.nlm.nih.gov/30418631/ | https://pubmed.ncbi.nlm.nih.gov/26554019/ | |||
| Vu | Ly | University of British Columbia | Faculty of Pharmaceutical Sciences | Terry Fox Laboratory - BC Cancer | ly.vu@ubc.ca | https://www.bccrc.ca/dept/tfl/people/ly-vu | We are interested in uncovering post-transcriptional gene expression regulation underlying stem cell function during normal blood development and malignant transformation. We focus on RNA modifications i.e. RNA methylation and deadenylation and how these processes mediate expression of oncogenic programs in myeloid leukemia. | RNA methylation, RNA deadenylation, RNA binding proteins, stem cells, hematopoiesis, leukemia | https://pubmed.ncbi.nlm.nih.gov/28920958/ | https://pubmed.ncbi.nlm.nih.gov/28436985/ | USE: m6a profiling; genome wide assessment of RBP bindings (RIP-seq; Hypertribe-seq) ; polyA tail length; transcriptional profiling | |
| Luo | Honglin | University of British Columbia | Pathology and Laboratory Medicine | honglin.luo@hli.ubc.ca | https://www.hli.ubc.ca/researchers/honglin-luo/ | RNA virology, RNA-binding proteins and neurodegenerative disease | Positive strand RNA viruses, autophagy, innate immunity, RNA-binding proteins, neurodegenerative disease, oncolytic virotherapy, myocarditis | https://pubmed.ncbi.nlm.nih.gov/33827951/ | https://pubmed.ncbi.nlm.nih.gov/33691586/ and https://pubmed.ncbi.nlm.nih.gov/29562184/ | Mouse model, gene expression analysis, protein degradation assays, cell culture, CRISPR-Cas9 | ||
| Sonenberg | Nahum | McGill University | Biochemistry | Goodman Cancer Institute, PI | nahum.sonenberg@mcgill.ca | http://www.med.mcgill.ca/nahum/ | Dr. Sonenberg studies the molecular basis of the control of protein synthesis in eukaryotic cells and its importance in diseases such as cancer, obesity, diabetes and neurological diseases. | mRNA, miRNA, translation, eIF4E, eIF4F, cancer, autism, neurodevelopment disease | https://pubmed.ncbi.nlm.nih.gov/20679199/ | https://pubmed.ncbi.nlm.nih.gov/19716330/ | ||
| Sagan | Selena | McGill University | Department of Microbiology & Immunology | Department of Biochemistry | selena.sagan@mcgill.ca | www.saganlab.com | Studying RNA at the host-virus interface | Virology, RNA biology, microRNAs, Hepatitis C virus, Dengue Virus, Zika virus, Respiratory Syncytial Virus | https://pubmed.ncbi.nlm.nih.gov/34385308/ | https://pubmed.ncbi.nlm.nih.gov/30941417/ | ||
| Glover | Mark | University of Alberta | Biochemistry | mark.glover@ualberta.ca | https://www.ualberta.ca/biochemistry/people/faculty/mark-glover.html | Our lab is interested in understanding the structural basis underlying interactions between protein and RNA. Specifically, we have researched how the FinO family of RNA chaperones selectively bind their sRNA targets and how these interactions facilitate sRNA - mRNA regulation. | X-ray crystallography; cryoEM; EMSA; biophysics; SAXS; RNA chaperones; protein-RNA interactions; RNA structural biology | https://pubmed.ncbi.nlm.nih.gov/21278162/ | https://pubmed.ncbi.nlm.nih.gov/25102058/ | X-ray crystallography; SAXS; fluorescence polarization; ITC; MALS | ||
| KAKUMANI | PAVAN | Memorial University of Newfoundland | Biochemistry | pavan.kakumani@mun.ca | Under Construction | small RNA guided gene regulation in health and disease | miRNAs, siRNAs, piRNAs, Argonaute, mRNA, retrotransposons, cell death, cell differentiation | https://pubmed.ncbi.nlm.nih.gov/33833398/ | https://pubmed.ncbi.nlm.nih.gov/32161113/ | NA | ||
| Rader | Stephen | University of Northern British Columbia | Chemistry | Affiliate Professor, University of British Columbia | rader@unbc.ca | https://web.unbc.ca/~rader/ | The Rader Lab investigates the biological function of introns. We have identified an alga, C. merolae, that has lost all but 38 of its introns, so we are now carrying out a variety of experiments to determine whether those that remain have an important function that precludes their elimination from the genome. | pre-mRNA splicing, spliceosome, splicing regulation, transcriptomics, red alga, Cyanidioschyzon merolae | https://pubmed.ncbi.nlm.nih.gov/25733880/ | https://pubmed.ncbi.nlm.nih.gov/28325844/ | We use transcriptomics (mostly through the Genome Sciences Centre at the BC Cancer Agency) and proteomics (also through the GSC). | |
| Fabian | Marc | McGill University | Oncology | Lady Davis Institute, Associate member, Department of Biochemsitry | marc.fabian@mcgill.ca | http://www.ladydavis.ca/en/marcfabianlab | Our lab is interested in RNA binding proteins that regulate mRNA translation and stability | mRNA translation, RNA binding proteins, PABP, RNA endonucleases, DICER, microRNA-mediated gene silencing | https://pubmed.ncbi.nlm.nih.gov/26027925/ | https://pubmed.ncbi.nlm.nih.gov/32510323/ | ||
| Cousineau | Benoit | McGill University | Microbiology & Immunology | benoit.cousineau@mcgill.ca | https://www.mcgill.ca/microimm/benoit-cousineau | Our lab studies splicing, mobility, evolution, and application of bacterial group II introns. | group II intron, RNA, ribozyme, splicing, mobility, evolution, bacteriology, molecular biology, microbiology, genetics. | 34157113 | 33118013 | McGill MI4 Microbiome Platform | ||
| Thakor | Nehal | University of Lethbridge | Chemistry and Biochemistry | Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary | nthakor@uleth.ca | https://www.ulethbridge.ca/artsci/biochemistry/thakor-group | Thakor lab is investigating the cellular, biochemical, molecular, and structural aspects of the regulation of protein synthesis. We are interested in delineating the molecular mechanisms of both canonical, and non-canonical translation initiation and determining how these processes impact tumourigenesis. | mRNA, non-canonical translation, Brain Tumor Stem Cells, GBM Xenograft Mouse model, eIFs | https://pubmed.ncbi.nlm.nih.gov/30670698/ | https://pubmed.ncbi.nlm.nih.gov/30551605/ | ||
| Russell | Tony | University of Lethbridge | Biological Sciences | Alberta RNA Research and Training Institute | tony.russell@uleth.ca | https://www.ulethbridge.ca/research/centres-institutes/alberta-rna-research-and-training-institute/russell-group | We identify and characterize ribonucleoprotein complexes in protist organisms. We are interested in structure-function relationships and evolution of these complexes in the main domains of life. | RNA Biology, Molecular Evolution, Bioinformatics, RNA-Seq, Intron and Spliceosome Evolution, SnoRNP complexes | https://pubmed.ncbi.nlm.nih.gov/23019220/ | https://pubmed.ncbi.nlm.nih.gov/21482665/ | Director, Alberta RNA Research and Training Institute | |
| Blanchette | Mathieu | McGill University | Computer Science | Mathieu Blanchette | http://www.cs.mcgill.ca/~blanchem | Bioinformatics and machine learning approaches in gene regulation. | Bioinformatics, machine learning, regulation, RNA, evolution, drug design, 3D genome organization | https://pubmed.ncbi.nlm.nih.gov/31937349/ | https://pubmed.ncbi.nlm.nih.gov/32657407/ | |||
| Ansari | Athar | Wayne State University | Biological Science | bb2749@wayne.edu | https://clasprofiles.wayne.edu/profile/bb2749 | The focus of my lab transcription by RNA polymerase II and co-transcriptional RNA processing. The research in my lab has shown that during transcription a gene assumes a unique looped architecture that helps cross-talk of different steps of transcription with each other as well as with co-transcriptional RNA processing events. | Eukaryotic transcription; cleavage-polyadenylation of mRNA; splicing of mRNA | https://academic.oup.com/nar/article/49/10/5520/6274539?login=true | https://www.frontiersin.org/articles/10.3389/fmolb.2021.669004/full | |||
| Lipshitz | Howard | University of Toronto | Molecular Genetics | howard.lipshitz@utoronto.ca | http://sites.utoronto.ca/flylab/ | Role of RNA-binding proteins in post-transcriptional regulation of gene expression. Focus is on (1) post-transcriptional processes during the maternal-to-zygotic transition in Drosophila; (2) using Drosophila to model rare human diseases caused by RNA-binding protein mutations; (3) role of RNA-binding proteins in autism. | RNA-binding protein, post-transcriptional regulation, transcriptome, synthetic antibody, maternal-to-zygotic transition, autism | PMID: 32579915 PMCID: PMC7372737 DOI: 10.1016/j.celrep.2020.107783 | PMID: 32160542 DOI: 10.1016/j.celrep.2020.02.066 | next generation sequencing, mass spectrometry | ||
| GATIGNOL | Anne | McGill University | Medicine | Microbiology & Immunology; Lady Davis Institute for Medical Research | anne.gatignol@mcgill.ca | http://ladydavis.ca/en/annegatignol | RNA therapies against HIV-1 to be used by gene therapy; small interfering RNAs against SARS-CoV2; microRNAs and HIV | RNA viruses; HIV; SARS-CoV2; siRNAs; shRNAs; miRNAs; TRBP; PKR; ADAR1; RNA binding proteins | https://pubmed.ncbi.nlm.nih.gov/33614248/ | https://pubmed.ncbi.nlm.nih.gov/25668122/ | ||
| Smibert | Craig | University of Toronto | Biochemistry | University of Toronto, Dept. of Molecular Genetics | c.smibert@utoronto.ca | http://biochemistry.utoronto.ca/person/craig-a-smibert/ | In my lab we are interested in understanding the molecular mechanisms that function to regulate gene expression in the cytoplasm. In the cytoplasm RNA-binding proteins and regulatory mRNAs act to control of mRNA translation, stability and subcellular localization by binding to target mRNAs. Our work employs the early Drosophila embryo as a model in which to study the function of RNA-binding proteins and non-coding RNAs in post-transcriptional regulation. | mRNA translation, mRNA stability, mRNA localization, RNA-binding proteins, Drosophila embryogenesis | https://pubmed.ncbi.nlm.nih.gov/25962635/ | https://pubmed.ncbi.nlm.nih.gov/24393533/ | ||
| Roussel | Marc | University of Lethbridge | Chemistry and Biochemistry | roussel@uleth.ca | http://people.uleth.ca/~roussel | We develop methods for modeling biochemical systems, ranging from tissue-level models down to cellular networks. The methods we use include differential equations and stochastic models, as appropriate. We have particular expertise in studying models with gene-expression delays. | chemical kinetics, nonlinear dynamics, stochastic systems | https://pubmed.ncbi.nlm.nih.gov/32413365/ | https://pubmed.ncbi.nlm.nih.gov/28608044/ | |||
| Wieden | Hans-Joachim | University of Manitoba | Microbiology | University of Lethbridge, Department of Chemistry and Biochemistry (Adjunct Professor) | hans-joachim.wieden@umanitoba.ca | https://sci.umanitoba.ca/micro/profiles/hjwieden/ | Our work focuses on the development of novel engineered expression platforms enabling innovative application addressing environmental and medical issues as well biotechnology. We study the molecular mechanisms of antibiotic function using a multidisciplinary approach based on advance biophysical methods in order to provide a framework for the development of novel antimicrobial strategies. Our research focuses on antibiotics that target the cellular machinery of the pathogen that is responsible for translating genetic information into functional proteins, a process called translation. | Ribosome, GTPases, Fluorescence, Antibiotics, Synthetic Biology, Structural Biology, Computational Biology, Rapid-kinteics, enzyme mechanism, regulatory RNAs, RNA structure and function | https://pubmed.ncbi.nlm.nih.gov/31058500/ | https://pubmed.ncbi.nlm.nih.gov/26733579/ | ||
| Cashman | Neil | University of British Columbia | Medicine | ProMIS Neurosciences | neil.cashman@vch.ca | https://www.centreforbrainhealth.ca/faculty/neil-cashman/ | Protein misfolding, including RNA binding proteins in disease (ALS and FTD). RNA therapeutics, such as ASOs, RNAi, and mRNA. | RNA binding proteins in disease (ALS and FTD). RNA therapeutics. | https://pubmed.ncbi.nlm.nih.gov/24550511/ | https://pubmed.ncbi.nlm.nih.gov/31736708/ | ||
| Waldispuhl | Jerome | McGill University | Computer Science | jerome.waldispuhl@mcgill.ca | http://csb.cs.mcgill.ca/ | RNA structure prediction, RNA / small molecules binding, structure modelling, | Algorithms, machine learning | https://pubmed.ncbi.nlm.nih.gov/32652015/ | https://pubmed.ncbi.nlm.nih.gov/34791045/ | |||
| Demeler | Borries | University of Lethbridge | Chemistry and Biochemistry | University of Montana (Dept. Chemistry and Biochemistry), University of Texas Health Science Center at San Antonio (Dept.of Biochemistry and Structural Biology) | demeler@gmail.com | http://cch.uleth.ca | Our laboratory explores interactions between biological macromolecules (proteins, RNA, DNA, lipids, carbohydrates) using biophysical approaches, in particular using analytical ultracentrifugation. We also develop software for the interpretation of hydrodynamic data from analytical ultracentrifugation experiments as well as hydrodynamic simulations (bead modeling, SAXS modeling, etc).simulation | analytical ultracentrifugation, high-performance computing | https://pubmed.ncbi.nlm.nih.gov/33617224/ | https://pubmed.ncbi.nlm.nih.gov/32559250/ | Canadian Center for Hydrodynamics (http://cch.uleth.ca) | |
| Unrau | Peter | Simon Fraser University | MBB | punrau@sfu.ca | https://www.rnabiochemistry.com/ | RNA Chemistry and Biology | RNA Tools, RNA Biology, RNA Chemistry. Origin of Life | 33737482, 29440634 | ||||
| Brill | Julie | University of Toronto | Cell Biology Program | The Hospital for Sick Children | julie.brill@sickkids.ca | https://www.sickkids.ca/en/staff/b/julie-brill/ | We are studying the roles, regulation and targets of testis-specific translation initiation factors (eIF4Es) in Drosophila. We are also studying the localization and functions of long noncoding RNAs in the Drosophila male reproductive tract. | translation initiation, sperm development, fertility, reproduction, Drosophila molecular genetics, cell biology, microscopy, biochemistry | https://pubmed.ncbi.nlm.nih.gov/22833128/ | https://www.biorxiv.org/content/10.1101/2021.12.19.473358v1 | We use the Imaging Facility and The Centre for Applied Genomics at The Hospital for Sick Children. | |
| Gingras | Anne-Claude | University of Toronto | Centre for Systems Biology | Lunenfeld-Tanenbaum Research Institute, Sinai Health; Department of Molecular Genetics | gingras@lunenfeld.ca | https://gingraslab.org/research/ | Dr. Gingras is an expert in mass spectrometry-based proteomics, a technology that enables the identification and quantification of proteins from biological samples. Her lab specializes in developing tools to better understand how proteins associate with one another to perform their functions. | mass spectrometry, interaction proteomics, protein-protein interactions, signal transduction, RNA biology, phase separation | https://pubmed.ncbi.nlm.nih.gov/34079125/ | https://pubmed.ncbi.nlm.nih.gov/29395067/ | mass spectrometry-based proteomics | |
| Maass | Philipp | University of Toronto | Genetics & Genome Biology | SickKids Research Institute ; University of Toronto, Department of Molecular Genetics | philipp.maass@sickkids.ca | https://lab.research.sickkids.ca/maass/ | Our central objective is to gain mechanistic insight into regulatory functions of the non-coding genome. In a systems biology approach covering the fields of genome & RNA biology, live-cell imaging, biochemistry, and computational biology, we address 1) how chromosomal territories are organized, 2) how inter-chromosomal contacts facilitate gene regulation and genome organization, and 3) how yet uncharacterized long non-coding RNA genes function to better understand biology and etiology of disease. | long non-coding RNAs, inter-chromosomal contacts, genome organization, functional genomics, non-coding disease mechanisms | https://pubmed.ncbi.nlm.nih.gov/30181316/ | https://pubmed.ncbi.nlm.nih.gov/23093776/ | ||
| Blencowe | Ben | University of Toronto | Donnelly Centre | Department of Molecular Genetics | b.blencowe@utoronto.ca | http://sites.utoronto.ca/intron/ | We study the regulation, function and evolution of RNA networks with critical roles in development and disease | RNA processing, alternative splicing, functional genomics, transcriptomics, nervous system development and disorders | https://pubmed.ncbi.nlm.nih.gov/25525873/ | https://pubmed.ncbi.nlm.nih.gov/18978789/ | University of Toronto - Donnelly Sequencing Centre | |
| LaPlante | Steven | INRS | Centre Armand Frappier Sante Biotechnologie | NMX Research and Solutions Inc, Harvard Medical School, Broad Institute | steven.laplante@inrs.ca | https://www.laplante-lab.com/research-overview | Our interests are centered on discovering drugs, tools and interesting chemical properties. Our team integrates protein/RNA expression and purification, biophysics fragment screening, and medicinal chemistry for lead/drug optimization. We bring years of pharma experienence to an academic/industry setting. | RNA, transcription factors, NMR, biophysics, fragment screening, drug discovery, FBLD, medicinal chemistry | PMID: 34707256 | PMID: 34699722 | NMR platform, Drug Discovery Biophysics Platform | |
| Cordes | Sabine | University of Toronto | Molecular Genetics | Lunenfeld-Tanenbaum Research Institute | cordes@lunenfeld.ca | none | RNA-based mechanisms in neurodevelopmental and mood disorders | Mouse Genetics, Autism Spectrum disorder, Neurodevelopment, serotonin, RNA transport, splicing | Quesnel-Vallieres, M et al. Mol Cell. 2016 Dec 15;64(6):1023-1034. doi: 10.1016/j.molcel.2016.11.033. PMID: 27984743 | Mol Gonatopoulos-Pournatzis, T et al. Cell. 2020 Mar 19;77(6):1176-1192.e16. doi: 10.1016/j.molcel.2020.01.006. Epub 2020 Jan 29. PMID: 31999954 | ||
| Ellis | James | University of Toronto | Developmental and Stem Cell Biology | The Hospital for Sick Children | jellis@sickkids.ca | https://lab.research.sickkids.ca/ellis/ | We aim to discover basic post-transcriptional regulatory mechanisms that control RNA levels, isoform structure and translation efficiency during human neurodevelopment. We strive to apply this knowledge through manipulation of induced pluripotent stem (iPS) cells to model human neurodevelopmental disorders and test potential therapies for precision medicine. | RNA stability, ribosome engagement, 3'UTR lengthening, pluripotent stem cells, neural progenitor cells, neurons, neurodevelopmental disorders | https://pubmed.ncbi.nlm.nih.gov/32209477/ | https://pubmed.ncbi.nlm.nih.gov/27732849/ | Genome Center (TCAG), Proteomics core (SPARK) | |
| Mekhail | Karim | University of Toronto | Laboratory Medicine and Pathobiology | karim.mekhail@utoronto.ca | https://www.mekhaillab.com | The Mekhail lab studies how the intersection of RNA and DNA regulatory processes control nuclear organization, genome stability, gene expression, and protein synthesis. These processes are investigated in the context of health and disease settings with a focus on cancers, neurodegenerative disorders, and viral infections.. | Ribosomal RNA, Non-coding RNA, Ribosome biogenesis, RNA-DNA hybrids, Nucleolus, Nuclear organization, Motor proteins, DNA repair, Homologous recombination, Non-homologous end-joining | https://pubmed.ncbi.nlm.nih.gov/32669707/ | https://pubmed.ncbi.nlm.nih.gov/18997772/ | Super-resolution microscopy, 3D image reconstruction | ||
| Morin | Gregg | University of British Columbia | Department of Medical Genetics | Genome Sciences Centre, BC Cancer Research Institute | gmorin@bcgsc.ca | https://www.bcgsc.ca/people/gregg-morin | The regulation of alternative RNA processing in cancer. Cancer proteomics. | alternative splicing, proteomics, mass spectrometry, genomics, CDK12/13, biochemistry | PMID: 2805070 | PMID: 28334900 | Head of the GSC Proteomics Platform: https://www.bcgsc.ca/services/proteomics | |
| Hope | Kristin | University of Toronto | Research, Princess Margaret Cancer Centre/Department of Medical Biophysics | University Health Network; Adjunt at cMaster University, OICR Investigator | kristin.hope@uhnresearch.ca | https://www.uhnresearch.ca/researcher/kristin-hope | We are interested in understanding the role of RNA binding proteins in normal and malignant hematopoietic stem cell function. By understanding the unique post-tanscriptional regulon of these proteins we aim to identify ways to harness their control to advance hematopoietic stem cell-based regenerative approaches and anti-leukemic therapies. | RNA binding proteins, hematopoietic stem cells, leukemic stem cells, post-transcriptional control, xenografts, primary human cells | https://pubmed.ncbi.nlm.nih.gov/27121842/ | https://pubmed.ncbi.nlm.nih.gov/29898370/ | Use animal, flow cytometry, microscopy, genomics and bioinformatics core facilities | |
| Wetmore | Stacey | University of Lethbridge | Department of Chemistry and Biochemistry | Alberta RNA Research and Teaching Institute | stacey.wetmore@uleth.ca | https://people.uleth.ca/~stacey.wetmore/ | The overarching objective of research done in the Wetmore lab is to use computer modeling to gain a fundamental understanding of the chemistry of modified nucleic acids. The long-term goals include uncovering how nucleic acids are modified and processed in our cells, and exploiting the properties of modified nucleic acids in novel biomedical/biotechnological applications. | computational chemistry, multi-scale (QM/MM) modeling, ab initio and density functional methods, molecular dynamics simulations, molecular structure and properties, (bio) reaction mechanisms, nucleic acids, DNA/RNA modifications, enzyme processing of nucleic acids | https://pubmed.ncbi.nlm.nih.gov/33214333/ | https://pubmed.ncbi.nlm.nih.gov/33544852/ | Compute/Calcul Canada | |
| Claycomb | Julie | University of Toronto | Molecular Genetics | julie.claycomb@utoronto.ca | claycomblab.com | Our research is focused on understanding the molecular mechanisms of how small RNA (sRNA) pathways regulate gene expression to influence fertility and animal development. We use C. elegans, a powerful model organism and champion of sRNA research, and we employ integrated molecular biology, biochemistry, genetics, genomics, and microscopy-based approaches in our work. | Argonaute, Small RNA, Gene Regulation, C. elegans, Epigenetics, RNAi, microRNA, piRNA, siRNA, RNA communication | https://pubmed.ncbi.nlm.nih.gov/34329465/ | https://pubmed.ncbi.nlm.nih.gov/24360783/ | |||
| Patel | Trushar | University of Lethbridge | Chemistry and Biochemistry | University of Calgary (Adjunct Associate Professor) | trushar.patel@uleth.ca | trpatel.com | The unifying theme of my lab is to employ interdisciplinary techniques to obtain detailed insights into how viral nucleic acids interact with human proteins. Information on the specific sites of human proteins that communicate with viral nucleic acids will ultimately allow the development of therapeutics that prevent host-viral communication. | Biophysics, Computational modeling, Small-angle X-ray scattering, Multi-angle light scattering, RNA structure studies, Flaviviruses, Non-coding RNAs, RNA-protein communication | https://pubmed.ncbi.nlm.nih.gov/33774051/ | https://pubmed.ncbi.nlm.nih.gov/32046304 | Synbridge Maker Space, DIAMOND Light Source, HPLC-MALS-DLS | |
| McKeague | Maureen | McGill University | Pharmacology & Therapeutics | Alberta RNA Research and Training Institute; Chemistry | Maureen.mckeague@mcgill.ca | https://mckeague.lab.mcgill.ca/ | Lee are interested in controlling and targeting the genome to better understand disease and develop therapeutics. | RNA therapeutics; gene control; genomic damage | ||||
| Wilson | Michael | University of Toronto | Molecular Genetics / Genetics and Genome Biology | SickKids Research Institute | michael.wilson@sickkids.ca | www.wilsonlab.org | We are interested in understanding gene and genome regulatory mechanisms that are relevant to developmental and disease processes. Current projects include looking at gene regulatory mechanisms underlying: early heart development; postnatal development and pubertal onset; and endothelial cell inflammation. We are also actively working on implementing RNA-seq in a clinical setting. | Comparative genomics, epigenomics, developmental biology, cardiovascular system, puberty, sex differences in gene regulation, RNA-seq, ChIP-seq, 3'UTR-seq, bioinformatics | https://pubmed.ncbi.nlm.nih.gov/33495464/ | https://pubmed.ncbi.nlm.nih.gov/30478328/ | The Centre for Applied Genomics (Illumina sequencing; automated 3'UTR-seq and RNA-seq platforms, and scRNA-seq); OICR (nanopore sequencing); SickKids/UHN Flow Facility; SickKids Imaging Core facility; The Centre for Phenogenomics; PMH genomics (single cell RNA-seq and ATAC-seq) | |
| Forman-Kay | Julie | University of Toronto | Molecular Medicine | Biochemistry Dept (status-only appointment) | forman@sickkids.ca | http://abragam.med.utoronto.ca/~JFKlab/ | The major aim of the lab is to provide biological insights into how intrinsically disordered proteins function in biology. The group uses NMR and other biophysical tools and develops computational tools to study disordered proteins and their interactions. Current research in the lab is focused on the role of phase separation of disordered protein regions with RNA in biomolecular condensates that control RNA processing, including effects of post-translational/post-transcriptional modifications and implications for cancer, autism and other diseases. | intrinsically disordered proteins, phase separation, biomolecular condensates, translational regulation, RNA processing, bioinformatics, NMR, biophysics | What are the distinguishing features and size requirements of biomolecular condensates and their implications for RNA-containing condensates? Forman-Kay JD, Ditlev JA, Nosella ML, Lee HO. RNA. 2022. 28(1):36-47. doi: 10.1261/rna.079026.121. PMID: 34772786 | Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation. Kim TH, Tsang B, Vernon RM, Sonenberg N, Kay LE, Forman-Kay JD. Science. 2019. 365(6455):825-829. doi: 10.1126/science.aax4240. PMID: 31439799 | Structural and Biophysical Core Facility, Hospital for Sick Children; NMR Centre, University of Toronto; Imaging Facility, Hospital for Sick Children; SPARC Molecular Analysis Mass Spectrometry, Hospital for Sick Children | |
| MacMillan | Andrew | University of Alberta | Biochemistry | andrew.macmillan@ualberta.ca | https://macmillanlab.biochem.ualberta.ca/ | Our lab is interested in the regulation of gene expression at the level of the RNA molecule. Our primary focus is the study of mechanisms of pre-mRNA splicing but we have also explored CRISPR mediated regulation, miRNA regulation and function, and RNA editing. | Gene regulation, RNA, pre-mRNA splicing, chemical biology, nucleic acids | https://pubmed.ncbi.nlm.nih.gov/23686287/ | https://pubmed.ncbi.nlm.nih.gov/16432215/ | mass spectrometry, X-ray diffraction | ||
| Frappier | Lori | University of Toronto | Molecular Genetics | lori.frappier@utoronto.ca | http://individual.utoronto.ca/frappierlab/lori.html | We study the roles of Epstein-Barr virus (EBV) proteins in manipulating cellular processes, largely using proteomic approaches. We have discovered EBV proteins that bind and manipulate RISC, CCR4NOT and Nup98/Rae1 thereby affecting miRNA function, mRNA stability and mRNA export. We are studying the functional consequences of these interactions both for the cell and the virus. | Epstein-Barr virus, miRNA, RISC, mRNA regulation, proteomics | https://pubmed.ncbi.nlm.nih.gov/35007297/ | mRNA and miRNA sequencing | |||
| Palazzo | Alexander | University of Toronto | Biochemistry | alex.palazzo@utoronto.ca | http://www.palazzolab.com | We investigate how mammalian mRNAs are packaged into messenger ribonucleoprotein (mRNP) complexes, how these are retained in the nucleus or exported to the cytoplasm, and how these mRNP complexes undergo maturation processes that affect their localization and the translation of the packaged mRNA into proteins. | mRNP, nuclear pore complex, RanBP2, RISC, sumoylation, endoplasmic reticulum, nuclear speckles, stress granules | https://pubmed.ncbi.nlm.nih.gov/33600493/ | https://pubmed.ncbi.nlm.nih.gov/30386371/ | Mammalian somatic cell microinjection station. | ||
| ZHANG | ZHAOLEI | University of Toronto | Donnelly Centre / Molecular Genetics / Computer Science | zhaolei.zhang@utoronto.ca | http://sites.utoronto.ca/zhanglab/ | bioinformatics, RNA binding proteins, microRNAs, noncoding RNAs | bioinformatics, RNA binding proteins, microRNAs, noncoding RNAs | computer servers | ||||
| Li | Yingfu | McMaster University | Biochemistry and Biomedical Sciences | liying@mcmaster.ca | yingfulilab.org | Our overall research interest is to examine molecular recognition and catalytic functions of artificial or natural single-stranded DNA or RNA molecules. We are particularly interested in investigating the potential of these molecules as diagnostics for the detection of infectious diseases caused by bacterial or viral pathogens. | Aptamers; DNAzymes; diagnostics; infectious diseases | https://pubmed.ncbi.nlm.nih.gov/34464491/ | https://pubmed.ncbi.nlm.nih.gov/34168325/ | McMaster Microbial Chemical Biology; McMaster Biointerfaces Institute | ||
| Joyce | Paul | Concordia University | Chemistry and Biochemistry | paul.joyce@concordia.ca | https://www.concordia.ca/artsci/biology/faculty.html.html?fpid=paul-joyce | We study the enzyme tRNA nucleotidyltransferase which is required to generate the 3'-terminal cytidine-cytidine-adenosine that is required in all mature tRNAs. This enzyme is involved in tRNA maturation, repair and quality control. We explore how defects in the enzyme leading to reduced functional tRNAs may be linked to human diseases, We are also interested in the evolution of this tRNA modification activity. | tRNA nucleotidyltransferase, maturation, quality control, localization, mitochondrion, nucleus | In vitro studies of disease-linked variants of human tRNA nucleotidyltransferase reveal decreased thermal stability and altered catalytic activity. Leibovitch M, Hanic-Joyce PJ, Joyce PBM. Biochim Biophys Acta Proteins Proteom. 2018 Apr;1866(4):527-540. doi: 10.1016/j.bbapap.2018.02.002. Epub 2018 Feb 16. | Schizosaccharomyces pombe contains separate CC- and A-adding tRNA nucleotidyltransferases. Reid NE, Ngou JS, Joyce PBM. Biochem Biophys Res Commun. 2019 Jan 15;508(3):785-790. doi: 10.1016/j.bbrc.2018.11.131. Epub 2018 Dec 6. | |||
| Autexief | Chantal | McGill University | Anatomy & Cell Biology | Chantal.autexier@mcgill.ca | http://www.ladydavis.ca/en/autexierlab | The maintenance and replication of functional chromosome ends, or telomeres, is essential for genome integrity and cell survival. Using cell culture models, we study how telomere maintenance and synthesis contribute to cell immortalization and cancer, and how defects in telomere maintenance contribute to various premature aging genetic disorders such as dyskeratosis congenita. | Telomere, telomerase, ribonuceoprotein, dyskerin, premature aging, cancer | https://pubmed.ncbi.nlm.nih.gov/30931479/ | https://pubmed.ncbi.nlm.nih.gov/32813614/ | |||
| Calarco | John | University of Toronto | Cell and Systems Biology | john.calarco@utoronto.ca | www.calarcolab.ca | We are interested in better understanding the mechanisms governing alternative splicing regulation across tissues and during development. Additionally, we are more broadly interested in how RNA binding proteins shape post-transcriptional regulatory networks in the developing and mature nervous system. We utilize the model organism C. elegans and mammalian cell culture systems to address these questions. | Alternative Splicing, transcriptomics, functional genomics, post-transcriptional gene regulation, genetics | https://pubmed.ncbi.nlm.nih.gov/24910101/ | https://pubmed.ncbi.nlm.nih.gov/33127752/ | We use several sequencing facilities at UofT, including the Donnelly Sequencing Centre, the Centre for Analysis of Genome Evolution and Function (CAGEF), and The Centre for Applied Genomics (TCAG) | ||
| Kulkarni | Jayesh | NanoVation Therapeutics | Research | N/A | j.kulkarni@nanovationtx.com | nanovationtx.com | NanoVation (NTx) is developing next-generation RNA therapeutics to enable extrahepatic gene therapy using lipid nanoparticles and RNA. | lipid nanoparticles, RNA, messenger RNA, gene therapy, delivery, LNP | https://pubmed.ncbi.nlm.nih.gov/29614232/ | https://pubmed.ncbi.nlm.nih.gov/31802031/ | ||
| Majumder | Mousumi | Brandon University | Biology | majumderm@brandonu.ca | https://people.brandonu.ca/majumderm/ | Roles of microRNA (miRNA) in breast cancer metastasis and tumor microenvironment regulation. Testing the potential of miRNA as breast cancer biomarker. | MicroRNA, Angiogenesis and Lymphangiogenesis, Oxidative Stress, Tumor Microenvironment, Cancer Stem cells, Biomarker Studies | https://pubmed.ncbi.nlm.nih.gov/27301070/ | https://pubmed.ncbi.nlm.nih.gov/34359739/ | Real time quantitative PCR, Biomarker analysis, Systems Biology, Bioinformatics, Hospital based based case-control study | ||
| Witzigmann | Dominik | NanoVation Therapeutics | NanoVation Therapeutics | d.witzigmann@nanovationtx.com | https://www.nanovationtx.com/ | NanoVation Therapeutics is offering an LNP toolbox to enable safe and efficient delivery of nucleic acids to a variety of (extra)hepatic tissues. | lipid nanoparticle, RNA, gene delivery, vaccine, gene editing | https://pubmed.ncbi.nlm.nih.gov/32622021/ | https://pubmed.ncbi.nlm.nih.gov/33495639/ | ext-generation lipid nanoparticle technologies tailored to a variety of tissues | ||
| richard | stephane | McGill University | Oncology and Medicine | Lady Davis Institute | stephane.richard@mcgill.ca | http://www.ladydavis.ca/en/stephanerichard | Arginine methylation of RNA binding proteins | cancer, prmts, RNA, QKI, clinical mouse models, | doi: 10.1016/j.jbc.2021.100821 | doi: 10.1016/j.celrep.2021.109337 | ||
| Ramalho-Santos | Miguel | University of Toronto | Molecular Genetics | Lunenfeld-Tanenbaum Research Institute | mrsantos@lunenfeld.ca | www.mrsantoslab.org | Our lab is interested in understanding the genome-environment interactions that shape mammalian development and reproduction. Of particular interest are pluripotent cells that exist in the mammalian embryo and give rise to all cell types of the body. | Stem cells, embryonic stem cells, pluripotency, pluripotent stem cells, transcription, chromatin, embryo, primordial germ cells, epigenetics | https://pubmed.ncbi.nlm.nih.gov/27880763/ | https://pubmed.ncbi.nlm.nih.gov/29937225/ | ||
| Cox | Brian | University of Toronto | Physiology | Obstetrics and Gynaecology | b.cox@utoronto.ca | https://physiology.utoronto.ca/faculty/brian-cox | Our focus is maternal fetal communication during pregnancy. Regulation of trophohlast and placental development and unbiased clusting of patient pathologies using multi-scale models. | RNA-sequencing, MicroRNA, development, pregnancy, placenta, maternal health, bioinformatics, computational modeling, | 28494860 | 27160201 | next generation sequecing, I own a Nextseq500 through a CFI award, Niagara High Performance Computer (SciNet/Canada Computes) | |
| Peng | Chun | York University | Biology | cpeng@yorku.ca | Peng.lab.yorku.ca | Role of microRNAs in regulating ovarian follicle development. Involvement of microRNAs pregnancy-related disorders and ovarian cancer. | microRNA, ovarian cancer, placental development, preeclampsia | https://pubmed.ncbi.nlm.nih.gov/30061037/ | https://pubmed.ncbi.nlm.nih.gov/29748371/ | |||
| Pearlman | Ronald | York University | Biology | ronp@yorku.ca | http://www.yorku.ca/ronp/ requires updating | Non-coding RNA and chromatin involved in developmentally programmed genome rearrangements/irreversible RNA-guided genome silencing. RNAi gene silencing. RNA binding proteins. Mediator in RNA transcription. Process of micro introns, 18-36 nucleotides. Annotation of small ncRNA. | small and long ncRNA; genome silencing, annotation of small ncRNA; transcription and Mediator; micro introns; ciliates | https://pubmed.ncbi.nlm.nih.gov/18708581/ | https://pubmed.ncbi.nlm.nih.gov/31280994/ | |||
| Jaramillo | Maritza | INRS | Centre Armand-Frappier Sante Biotechnologie | maritza.jaramillo@inrs.ca | https://inrs.ca/la-recherche/professeurs/maritza-jaramillo/ | Dysregulation of host mRNA turnover and translation during toxoplasmosis and leishmaniasis | mRNA translation, mRNA turnover, RNA-binding proteins, innate immunity, parasitic infections | https://pubmed.ncbi.nlm.nih.gov/32479529/ | https://pubmed.ncbi.nlm.nih.gov/29967092/ | ImageStreamX, confocal microscopy, Flow cytometry, IRIC genomics plaform | ||
| White | K. Andrew | York University | Biology | kawhite@yorku.ca | http://biology.gradstudies.yorku.ca/faculty/a-white/ | Our research group is interested in RNA-mediated control of RNA virus processes. Specifically, RNA replication, RNA transcription, translational regulation and RNA genome packaging. | RNA virus, RNA-based regulation, RNA-RNA interactions, RNA structure, RNA folding, RNA-protein interactions | doi: 10.1093/nar/gkaa675. | doi: 10.1038/nrmicro3288. | |||
| Meneghini | Marc | University of Toronto | Molecular Genetics | marc.meneghini@utoronto.ca | https://www.meneghinilab.com | Although the budding yeast Saccharomyces cerevisiae is chronically infected with a double-stranded RNA virus called L-A, the lack of any known fitness consequence of L-A has hindered use of this model organism for the study of host-virus interactions. We have discovered that L-A causes lethal pathogenesis in cells lacking parallel-acting viral attenuation pathways. Leveraging this discovery, we are exploiting forward genetic and hypothesis driven experiments to discover and characterize new anti-viral mechanisms. | budding yeast, RNA virus, mitochondria, sporulation, programmed cell death, innate immunity, proteostasis | https://pubmed.ncbi.nlm.nih.gov/31266891/ | https://pubmed.ncbi.nlm.nih.gov/22727375/ | |||
| Krause | Henry | University of Toronto | Donnelly Centre | Department of Molecular Genetics | h.krause@utoronto.ca | http://sites.utoronto.ca/krause/file/Krause_lab.html | One of our new aims is understanding the evolution and function of lncRNAs, particularly in male reproductive tissues. | Long noncoding RNAs, RNA localization | DOI: 10.1101/gad.276931.115 | DOI: 10.1016/j.tig.2017.08.002 | Drosophila gene expression database: Fly-FISH: http://fly-fish.ccbr.utoronto.ca | |
| Hughes | Tim | University of Toronto | Molecular Genetics and Donnelly Centre | t.hughes@utoronto.ca | http://hugheslab.ccbr.utoronto.ca | Decoding gene regulation: we determine what sequences and structures are recognized by DNA and RNA binding proteins, and study how they work in combination | Motifs, SELEX, ChIP-seq, computational biology, microarrays, MPRAs, retroelements, transposons, nucleosomes, regulatory sites | https://pubmed.ncbi.nlm.nih.gov/23846655/ | https://pubmed.ncbi.nlm.nih.gov/32703884/ | |||
| Pelchat | Martin | University of Ottawa | Biochemistry, Microbiology and Immunology | mpelchat@uottawa.ca | https://med.uottawa.ca/bmi/en/people/pelchat-martin | My team studies how host proteins are used by RNA viruses for their life cycle using various virology, biochemistry, bioinformatics, molecular and cellular biology. We also perform bioinformatics analyses of viral populations and RNA elements to identified several conserved sequences and motifs that might be important for their replication and pathogenesis. | RNA:protein binding assays, Transcription, High-throughput sequencing, Computational biology | |||||
| Youn | Ji-Young | University of Toronto | Molecular Medicine | SickKids Research Institute | jiyoung.youn@sickkids.ca | https://www.sickkids.ca/en/staff/y/ji-young-youn/ | Stress halts cells from producing new proteins, and stress granules form in the cytoplasm when the proteins and RNAs involved in these processes partition themselves into discrete droplets, much like oil does in water. We are interested in understanding how several hundreds of proteins concentrate into stress granules and how they are organized. We employ discovery-based proteomics techniques and cell biological tools to understand this question. We currently focus on i) investigating stress granule proteomes in various stress contexts, ii) characterizing the roles for intrinsically disordered proteins, iii) identifying protein-protein interactions important for stress granule formation and disassembly. We are also interested in understanding the relationship between stress granules and disease, specifically neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). | Stress Granule, proximity-dependent biotinylation (BioID), protein-protein interaction, phase separation, biomolecular condensates, amyotrophic lateral sclerosis, frontotemporal dementia, RNA-binding proteins, translation | https://pubmed.ncbi.nlm.nih.gov/29395067/ | https://pubmed.ncbi.nlm.nih.gov/31626750/ | Mass spectrometry for BioID | |
| Charette | Michael | Brandon University | Chemistry | Children's Hospital Research Institute of Manitoba, CancerCare Manitoba Research Institute | Charettem@brandonu.ca | https://people.brandonu.ca/charettem/ | Our lab is interested in elucidating the molecular mechanisms of ribosomal SSU assembly by the SSU processome, the molecular pathogenesis of ribosome assembly disorders/ribosomopathies, and the relationship between ribosome assembly an cell growth. | Ribosome assembly, SSU processome, ribosomopathies, RNA helicases, translation fidelity, intrinsically disordered proteins, yeast models of disease, yeast two-hybrid, co-IPs, protein-protein interactions | https://pubmed.ncbi.nlm.nih.gov/25877921/ | https://pubmed.ncbi.nlm.nih.gov/17051219/ | ||
| Condon | Anne | University of British Columbia | Computer Science | condon@cs.ubc.ca | cs.ubc.ca/~condon | DNA computing and molecular programming | Algorithms, thermodynamic and kinetic models, structure and folding pathway prediction | https://pubmed.ncbi.nlm.nih.gov/17646296/ | https://pubmed.ncbi.nlm.nih.gov/12824338/ | |||
| Dick | John | University of Toronto | Molecular Genetics | Princess Margaret Cancer Centre | john.dick@uhnresearch.ca | jdstemcellresearch.ca | The long-term goal of our research program is to elucidate the mechanisms underpinning the stemness state of human hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) and to transform these findings into new therapies and biomarkers. Simply put, guided by these fundamental research questions: What makes a stem cell a stem cell? Which stem cell properties are shared between HSCs and LSCs? Which are different? How do HSCs transform into LSCs? | miRNA, AGO, human hematopoiesis, stem cells, leukaemia stem cells | PMID: 34244384 | PMID: 26832662 | flow, genomics, animal | |
| Greenblatt | Jack | University of Toronto | Donnelly Centre | jack.greenblatt@utoronto.ca | sites.utoronto.ca/greenblattlab/ | We study genome organization and gene regulation by the >700 human C2H2 zinc finger proteins, with a special emphasis on the roles of RNA-binding by these proteins on transcriptional and post-transcriptional gene regulation. Other projects focus on virus-host interactions for the human tumour viruses and other viruses with RNA genomes. | C2H2 zinc finger proteins, transcription termination, RNA polymerase II, protein-RNA interactions, genome organization, post-transcriptional regulation, virus-host interactions, SARS-CoV-2, mass spectrometry, CLIP-sequencing | iScience. 2022 Jan 21;25(1):103562. doi: 10.1016/j.isci.2021.103562. Epub 2021 Dec 4 | Mol Cell. 2017 Feb 2;65(3):539-553.e7. doi: 10.1016/j.molcel.2017.01.011 | Mass spectrometry; CL2+ tissue culture facility | ||
| Kothe | Ute | University of Manitoba | Chemistry | Adjunct Professor, University of Lethbridge | ute.kothe@umanitoba.ca | kothegroup.ca | In the Kothe group, we are interested in understanding how functional RNAs are generated focusing on RNA modification, RNA folding and RNA processing. We investigate structure-function relationships of RNAs and proteins aiding in RNA biosynthesis with the aim to understand fundamental processes in life as well as molecular causes of diseases such as cancer and inherited syndromes. Our special focus lies on studying tRNA biosynthesis as well as ribosome biogenesis. To address our research questions, we apply a combination of techniques in biochemistry, biophysics, molecular biology, and genetics using bacterial, yeast and human cells. | enzymology, RNA-protein interaction studies, enzyme kinetics, fluorescence, RNA structure probing, molecular biology, E. coli & S. saccharomyces genetics, phenotypic analysis, transcriptomics | https://pubmed.ncbi.nlm.nih.gov/27849601/c | https://pubmed.ncbi.nlm.nih.gov/29177505/ | ||
| Park | Jeehye | University of Toronto | Genetics and Genome Biology Program | SickKids Research Institute; Department of Molecular Genetics | jeehye.park@sickkids.ca | https://lab.research.sickkids.ca/park/ | The Park Lab is interested in understanding the molecular mechanisms underlying neurodegenerative diseases with the aim of identifying targetable pathways for therapeutic interventions. Our studies use multidisciplinary approaches including biochemistry, molecular cell biology, and Drosophila and mouse genetics. | Neurodegenerative diseases, amyotrophic lateral sclerosis, neurodegeneration, neuroinflammation, RNA binding protein, mouse models, Drosophila, genetics, molecular biology, RNA profiling | https://pubmed.ncbi.nlm.nih.gov/33082323/ | https://pubmed.ncbi.nlm.nih.gov/32515490/ | ||
| Zovoilis | Athanasios | University of Lethbridge | Chemistry and Biochemistry | Director, Southern Alberta Genome Sciences Centre | athanasios.zovoilis@uleth.ca | www.genome-intelligence.org | Our lab focuses on the role of non coding RNAs in health and disease and the development of RNA bioinformatics tools for the analysis of transcriptomes and epitrancriptomes. | RNA bioinformatics, transcriptomics, epitranscriptomics, Nanopore sequencing | https://pubmed.ncbi.nlm.nih.gov/27984727/ | https://pubmed.ncbi.nlm.nih.gov/33191914/ | Director, SAGSC Bioinformatics Core | |
| Lee | Hyun | University of Toronto | Biochemistry | hyunokate.lee@utoronto.ca | http://biochemistry.utoronto.ca/person/hyun-kate-lee/ | how the organization of RNA binding proteins and RNA is regulated in cells and its impact on protein/RNA function | phase separation, biomolecular condensates, microscopy, biochemistry, biophysics | |||||
| Damha | Masad | McGill University | Chemistry | masad.damha@mcgill.ca | http://damha-group.mcgill.ca/ | Design, chemical synthesis of oligonucleotide therapeutics (ASO, siRNA, aptamers, crRNA, bRNA); study of non-canonical DNA structures; | solid-phase synthesis, mechanochemical synthesis; nucleic acid modifications; biophysical studies of DNA & RNA structure. | https://pubmed.ncbi.nlm.nih.gov/?term=damha+m | ||||
| Unrau | Peter | Simon Fraser University | Molecular Biology and Biochemistry | punrau@sfu.ca | https://www.rnabiochemistry.com/ | RNA and it role in the origin and evolution of life. | RNA, ribozyme, aptamer, fluorogenic aptamer | 33737482 | 29440634 | |||
| Roberts | Luc | University of Lethbridge | Chemistry and Biochemistry | Allos Bioscience | luc@allosbioscience.com | www.allosbioscience.com | Carbohydrates, Biosensors, Proteins | Biosensor, Protein, Fluorescence, Molecular Dynamics, Simulation, Carbohydrate, Maltose, Pectin | Computational Identification of Non-disruptive Conjugation sites (CINC) | |||
| McKenna | Sean | University of Manitoba | Chemistry | sean.mckenna@umanitoba.ca | http://home.cc.umanitoba.ca/~mckenna/ | In our laboratory we seek to obtain a molecular understanding of how transient protein-nucleic acid recognition events affect enzymatic activity in important biological systems. We use methods of structural biology to study the features of a biological system, and complement the structural data with mechanistic biophysical, biochemical, and molecular biology methods. | RNA-protein interactions, non-coding RNA, Quadruplex, structural biology, innate immunity | 28651607 | 28472472 | |||
| Duchaine | Thomas | McGill University | Biochemistry | Goodman Cancer Institute | thomas.duchaine@mcgill.ca | https://thomasduchainelab.wordpress.com/ | The overarching goal of our research program is to understand the molecular basis for the gene-regulation functions of the RNAi mechanisms, and to translate into cancer-relevant, and actionable knowledge. Our research program relies on integrated biochemistry, genetics, and proteomics approaches to explore newly discovered RNAi-related phenomena both in C. elegans and in cancer systems. | RNA-mediated silencing, RNAi, microRNA, 3'-untranslated region, chromatin regulation, genetics, proteomics, epigenetics, C. elegans, RNA-binding proteins, regulation of gene expression | ||||
| DeWitte-Orr | Stephanie | Wilfred Laurier University | Health Sciences | Adjunct Professor, University of Waterloo | sdewitteorr@wlu.ca | https://www.wlu.ca/academics/faculties/faculty-of-science/faculty-profiles/stephanie-dewitte-orr/index.html | We study virus-derived, long, double-stranded (ds)RNA and its ability to modulate the innate antiviral immune response in vertebrates. We investigate both the type I interferon response and the RNA interference (RNAi) pathway, specifically focusing on how we can use dsRNA to modulate these pathways to develop novel antivirals. | dsRNA, RNAi, type I interferons, vertebrates, nanoparticles, cell lines, microscopy, molecular biology | https://pubmed.ncbi.nlm.nih.gov/31541160/ | https://pubmed.ncbi.nlm.nih.gov/34999226/ | in vitro transcription, nanoparticle conjugation | |
| Kleinman | Claudia | McGill University | Human Genetics | Lady Davis Institute, Jewish General Hospital | claudia.kleinman@mcgill.ca | functionalgenomics.ca | Regulatory processes underlying disease, particularly focused on cancer and brain development | transcriptomics, computational biology, bioinformatics, single-cell biology, epigenomics, systems biology, machine learning | 31768071 | 33259802 | ||
| Vera Ugalde | Maria | McGill University | Biochemistry | maria.veraugalde@mcgill.ca | http://www.veraugaldelab.net/ | The Vera Ugalde lab uses single-molecule fluorescence microscopy approaches to investigate the spatiotemporal regulation of Heat Shock Protein mRNAs following stresses. We aim to uncover the mechanisms that tailor the expression of HSPs to survive stress and how its deregulation leads to neurodegeneration. | mRNA, translation, mRNA decay, Heat Shock Proteins, single-molecule fluorescence microscopy, neurodegeneration, mRNA localization | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843578/ | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164936/ | Quantitative Fluorescence Microscopy | ||
| Cui | Haissi | University of Toronto | Chemistry | haissi.cui@utoronto.ca | haissicui-lab.ca | We use chemical tools to understand and manipulate how RNA maturation and decoding are spatially regulated in the etiology of human disease. We combine small molecule compounds, protein and genome engineering, and cell biology to understand how the localization of RNA and protein in the cell can impact inflammation as well as neurological and developmental disorders. The long-term goal of the lab is to translate this understanding into potential avenues for therapeutics but also to follow our curiosity and study new and unexpected functions of biomolecules. | tRNA, aminoacyl-tRNA synthetase, multisynthetase complex, mRNA translation, mRNA processing, splicing, nuclear organization, cellular organization, leukodystrophy | https://pubmed.ncbi.nlm.nih.gov/33341895/ | https://www.biorxiv.org/content/10.1101/2021.09.07.459304v2.full | biochemistry and tissue culture, NGS, proteomics | ||
| Luedtke | Nathan | McGill University | Chemistry | Pharmacology and Therapeutics | nathan.luedtke@mcgill.ca | http://www.bioorganic-chemistry.com/index.html | We working on fluorescent RNA/DNA labeling strategies and their precision oncology applications. These include RNA targeting by nucleoside drugs and therapeutic oligonucleotides (ex. saRNA) for treating specific subtypes of AML | chemical biology, bioorthogonal "click" chemistry, fluorescent probes, precision oncology, therapeutic oligonucleotides, lipid nanoparticles, acute myeloid leukemia | https://pubs.acs.org/doi/10.1021/acsptsci.0c00120 | https://www.pnas.org/doi/abs/10.1073/pnas.1714790115 | ||
| Ndao | Momar | McGill University | Medicine | momar.ndao@mcgill.ca | https://ndaolabmcgill.wixsite.com/website/research or www.nrcp.ca | Dr. Ndao research topics are broad and include: 1) the diagnosis of parasitic diseases, 2) the study of host-parasite interactions, 3) screening drugs to be used as therapies for protozoan parasitic disease, 4) developing vaccines to prevent parasitic diseases, and 5) applying proteomic technology to discover biomarkers for infectious diseases. | Vaccine, diagnostic, drug screening, proteomic, metabolomic, immunology, parasitology, infectious diseases | https://pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca/35500538/ | https://pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca/33304354/ | Research Institute of the McGill University Health Centre | ||
| Audas | Timothy | Simon Fraser University | Molecular Biology and Biochemistry | taudas@sfu.ca | http://www.sfu.ca/mbb/research/featured-research/Tim-Audas-lab-page/audas-group.html | The Audas lab studies the formation of physiological amyloid aggregates. These stress-inducible structures are formed through the recruitment of a diverse array of cellular proteins by a family of long non-coding RNA derived from the rDNA intergenic spacers. | Cellular Stress, Protein Aggregation, architectural RNA, Amyloids, Heat Shock, Subnuclear Domains | https://pubmed.ncbi.nlm.nih.gov/22284675/ | https://pubmed.ncbi.nlm.nih.gov/27720612/ | |||
| Topisirovic | Ivan | McGill University | Lady Davis Institute/Oncology | ivan.topisirovic@mcgill.ca | https://www.ladydavis.ca/en/ivantopisirovic | We are interested in studying the networks that orchestrate perturbations in post-transcriptional mechanisms of gene expression (e.g., mRNA translation), signaling and metabolism in homeostatic adaptation to stress as well as their dysregulation in pathological states including cancer. | mRNA translation, post-transcriptional regulation of gene expression, signaling, mRNA metabolism, energy metabolism | https://pubmed.ncbi.nlm.nih.gov/31556460/ | https://pubmed.ncbi.nlm.nih.gov/30244971/ | McGill Metabolomics Facility | ||
| Chen | Guojun | McGill University | Biomedical Engineering | guojun.chen@mcgill.ca | https://www.guojunchenlab.org/ | My lab focuses on engineering intelligent drug delivery system for a variety of cargos, including nucleic acids, for treating various diseases. | Drug delivery, Nanotechnology, Biomaterials, Gene therapy, Genome editing, Cancer immunotherapy, RNA delivery, Cold plasma therapy | https://pubmed.ncbi.nlm.nih.gov/31501532/ | https://pubmed.ncbi.nlm.nih.gov/29798662/ | |||
| Lin | Rongtuan | McGill University | Medicine | Lady Davis Institute | Rongtuan.lin@mcgill.ca | https://www.ladydavis.ca/en/rongtuanlin | Our interest is to characterize the positive and negative regulation of antiviral response, determine the impact of virus-host cell interactions on the initiation and regulation of innate immune signaling, and develop novel strategies to control and prevent virus infection. | 5'pppRNA, innate immunity, IFN signaling, viral evasion. | ||||
| Liang | Chen | McGill University | Medicine | Lady Davis Institute | chen.liang@mcgill.ca | https://www.ladydavis.ca/en/chenliang | Our research uses molecular, genomic and proteomic approaches to understand the complex interactions between viruses and hosts, with focus on the antiviral innate immune responses to pathogenic RNA viruses including HIV-1 and SARS-CoV-2. We discovered the anti-HIV-1 activity of the interferon-stimulated genes IFITM and MxB which restrict the early steps of HIV-1 infection and belong to a short list of known HIV-1 restriction factors. We pioneered the application of the CRISPR gene editing technology in curing HIV-1 infected cells by cleaving and eliminating the integrated viral DNA. | HIV, SARS-CoV-2, RNA-binding proteins, helicases, innate immunity, interferon, CRISPR, antiviral drugs | https://pubmed.ncbi.nlm.nih.gov/24055605/ | https://pubmed.ncbi.nlm.nih.gov/27068471/ | ||
| Hoesli | Corinne | McGill University | Chemical Engineering | corinne.hoesli@mcgill.ca | www.hoeslilab.ca | Interactions of RNA therapeutics with stem cell-derived, vascularized and/or 3D printed tissue models | cell therapy, tissue engineering, 3D printing, flow models, stem cells | https://pubmed.ncbi.nlm.nih.gov/31988329/ | https://pubmed.ncbi.nlm.nih.gov/33036618/ | Manage: Bioprinting (3DDiscovery). Use: MUHC Human Islet Transplantation Laboratory | ||
| Pelletier | Jerry | McGill University | Biochemistry | jerry.pelletier@mcgill.ca | http://www.jerrypelletierlab.com/ | We combine chemical biology, molecular genetic, and genome editing tools to understand how eukaryotic translation initiation regulates and molds the cellular proteome. As well, by integrating our approaches with powerful cancer models we seek to understand how translation can be targeted as a vulnerability in cancer progression and drug resistance. | Translation Regulation, Protein Synthesis, eIF4F, eIF4A, DEAD-box Helicase, Chemical Biology, Rocaglates, Pateamine, Hippuristanol | https://pubmed.ncbi.nlm.nih.gov/31220979/ | https://pubmed.ncbi.nlm.nih.gov/33412110/ | |||
| Moitessier | Nicolas | McGill University | Chemistry | CSO, Molecular Forecaster | nicolas.moitessier@mcgill.ca | http://moitessier-group.mcgill.ca | Medicinal chemistry and software development | Docking, Drug design and discovery, Parkinson's disease, Antibiotics. | https://pubmed.ncbi.nlm.nih.gov/30831409/ | https://pubmed.ncbi.nlm.nih.gov/28899099/ | Computational drug discovery platform (Forecaster) | |
| Weber | Stephanie | McGill University | Biology | Physics Department, McGill University | steph.weber@mcgill.ca | https://weberlab.ca/ | The Weber Lab uses quantitative live-cell imaging and physical modeling to understand how biological systems establish and dynamically regulate spatial organization. Ultimately, we are interested in determining how these processes affect the growth, size and health of individual cells, multicellular organisms and whole ecosystems. | Phase separation, Membraneless organelles, Transcription, Nucleolus, Ribosome biogenesis, Size scaling, Cellular biophysics, Spatial organization | https://pubmed.ncbi.nlm.nih.gov/32675239/ | https://pubmed.ncbi.nlm.nih.gov/26351690/ | N/A | |
| Duraikannu Kailasam | Senthil Kumar | McGill University | Human Genetics | guil.bourque@mcgill.ca | https://computationalgenomics.ca/ | Transcriptomics, RNA-protein interaction | Bioinformatics, RNAseq, CLIP-seq, Ribosome profiling, SHAPE-seq, CrisPR-seq, MD simulation, | https://pubmed.ncbi.nlm.nih.gov/31339905/ | https://pubmed.ncbi.nlm.nih.gov/29026195/ | genpipes, McGill Genome center, C3G | ||
| Langlais | David | McGill University | Human Genetics | McGill Genome Centre | david.langlais@mcgill.ca | www.langlaislab.com | The Langlais lab investigates the epigenetic regulatory mechanisms of RNA expression in the context of normal and pathological inflammation. | functional genomics, transcription, epigenetics, innate immunity, inflammation, infection, host-pathogen interaction, single-cell omics | PMID: 35648852 | PMID: 34858388 | ||
| Larijani | Mani | Simon Fraser University | Molecular Biology and Biochemistry | mani_larijani@sfu.ca | www.larijani-lab.ca | Mechanisms, evolution and biological roles of DNA/RNA-editing enzymes | DNA mutations, RNA, DNA/RNA hybrids, enzymes, evolution, immunity, cancer | https://pubmed.ncbi.nlm.nih.gov/34423273/ | https://pubmed.ncbi.nlm.nih.gov/29161581/ | enzyme expression and purification and enzyme assays | ||
| Zerges | William | Concordia University | Biology | william.zerges@concordia.ca | https://zergeslab.github.io/ | We study translation control and localization for targeting proteins to and within chloroplasts. We also study oxidized RNA metabolism and translation quality control in yeast . | translation, mRNA, ribosome, organelle, chloroplast, oxidized RNA, Chlamydomonas, yeast | https://pubmed.ncbi.nlm.nih.gov/31591163/ | https://pubmed.ncbi.nlm.nih.gov/27379123/ | |||
| Howard | Perry | University of Victoria | Biochemistry and Microbiology | phoward@uvic.ca | https://www.uvic.ca/science/biochem/people/faculty/profiles/howard.php | The life of an RNAPII RNA is highly coordinated from the beginning of transcription to degradation. This coordination of recruitment, assembly, disassembly of RNA-protein complexes plays a critical role in cellular responses to stress and underpins many pathological processes. My lab studies the role of the nuclear cap complex in RNA metabolism. | cap complex; RNA biogenesis, nonsense mediated decay, Ars2, CBP, retina, muscle, IRES, Aniridia, target protectors, MODY, Pax6 | https://pubmed.ncbi.nlm.nih.gov/35104878/ | https://pubmed.ncbi.nlm.nih.gov/30673303/ | UVic Genome BC Proteomics Centre | ||
| Liu | Juewen | University of Waterloo | Chemistry | liujw@uwaterloo.ca | https://science.uwaterloo.ca/~liujw/index.html | Selection of DNA aptamers that can bind to important metabolites, environmental contaminants and metal ions; selection of metal-specific DNAzymes and ribozymes for the RNA cleavage reactions. Biosensor development using the selected aptamers and DNAzymes. | Aptamers, DNAzymes, ribozymes, biosensors, nanomaterials | https://pubmed.ncbi.nlm.nih.gov/35943093/ | https://pubmed.ncbi.nlm.nih.gov/31867832/ | |||
| Nelson | Chris | University of Victoria | Biochemistry and Microbiology | cjn@uvic.ca | https://www.uvic.ca/science/biochem/people/faculty/index.php | Application of molecular and systems-biology approaches to the study of chromatin regulatory pathway in yeast and mammalian cells. Current areas of investigation include transcription, RNA metabolism and DNA repair pathways involved in normal and cancer biology. | Chromatin, histone chaperones, epigenetics, transcription and stability of nucleolar rDNA; yeast systems biology. | https://pubmed.ncbi.nlm.nih.gov/29361176/ | https://pubmed.ncbi.nlm.nih.gov/31604797/ | |||
| Furber | Kendra | University of Northern British Columbia | Division of Medical Sciences | kendra.furber@unbc.ca | https://www2.unbc.ca/people/furber-dr-kendra | My research program investigates myelination across the lifespan, including the epigenetic and transcriptional regulation of oligodendrocyte differentiation. | aging, neurodegeneration, myelination, transcriptomics, proteomics | |||||
| Meier-Stephenson | Vanessa | University of Alberta | Medicine / Medical Microbiology and Immunology | Li Ka Shing Institute of Virology | meierste@ualberta.ca | https://sites.google.com/view/meierstephensonlab/home?authuser=0 | Our lab is looking at the interplay of viral nucleic acids with host proteins, with a focus on hepatitis B and D viruses. We use a variety of biophysical and virologic approaches to study the interactions in vitro and in vivo for the purposes of therapeutics design. | Viral hepatitis, viral-host protein interactions, G-quadruplexes, RNA hairpins, drug design, | https://www.sciencedirect.com/science/article/pii/S0021925821003690 | https://doi.org/10.1007/s12551-022-00952-8 | Bacterial expression platforms, affinity and SEC chromatography, MST, (soon to have on-site) CryoEM, cell culture/infection studies, luciferase reporter assays, qPCR, | |
| Pelletier | Jerry | McGill University | Biochemistry | jerry.pelletier@mcgill.ca | http://www.jerrypelletierlab.com/ | We apply chemical biology approaches to dissect and understand the fundamental principles of eukaryotic protein synthesis. With a focus on translation initiation our lab has identified and characterized unique natural products that selectively target this process. A significant portion of our research program aims to understand the molecular mechanism of action of these compounds. | translation, RNA helicase, eIF4A, rocaglates, pateamines, hippuristanol, gene expression, eIF4F, | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626061/ | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515738/ | |||
| Golshani | Ashkan | Carleton University | Biology | golshaniashkan@gmail.com | https://carleton.ca/biology/people/ashkan-golshani/ | translation of structured mRNA structure | computational analysis, mRNA, translation, yeast, protein-protein interaction, peptide drugs | https://pubmed.ncbi.nlm.nih.gov/35598219/ | https://pubmed.ncbi.nlm.nih.gov/36004308/ | |||
| McKay | Bruce | Carleton University | Biology | Bruce.mckay@carleton.ca | https://carleton.ca/biology/people/bruce-mckay/ | We study postranscriptional regulation of gene express and cellular responses alterations on RNA processing. | mRNA stability, pre-mRNA splicing, transcription stress, splicing stress, genetic engineering | https://pubmed.ncbi.nlm.nih.gov/34419492/ | https://pubmed.ncbi.nlm.nih.gov/22020975/ | Flowcytometry, qRT-PCR, tandem guide CRISPR | ||
| Patterson | Ian | Brock University | Biological Sciences | ipatterson@brocku.ca | https://brocku.ca/mathematics-science/biology/directory/ian-patterson/ | Our research aims to characterize viruses that infect arthropods. The main focus is on virus transmission and manipulating the virome to reduce vector competence. | RNA viruses; arboviruses; insect-specific viruses; paratransgenesis | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223947/ | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302987/ | CL3 facilities | ||
| Tong | Yufeng | University of Windsor | Chemistry and Biochemistry | ytong@uwindsor.ca | https://tonglab.ca | We use work on protein-RNA interactions using structural biology and biophysics techniques. | cell signaling; protein engineering | https://pubmed.ncbi.nlm.nih.gov/26489670/ | https://pubmed.ncbi.nlm.nih.gov/27255711/ | biophysics | ||
| Ananvoranich | Sirinart | University of Windsor | Chemistry and Biochemistry | anans@uwindsor.ca | https://www.uwindsor.ca/people/ananvoranich/ | noncoding RNA, parasitic infection, RNA interference, functional analysis | molecular biology, cell cultures, gene expression | doi: 10.1016/j.molbiopara.2020.111334 | doi: 10.1016/j.molbiopara.2020.111349 | |||
| Karpowicz | Phillip | University of Windsor | Biomedical Sciences | Phillip Karpowicz | http://www.karpowiczlab.ca | Circadian rhythms in the digestive tract. Intestinal stem cells and regeneration in mouse and Drosophila. Circadian rhythms in Inflammatory Bowel Disease and Colorectal Cancer. | Circadian, intestine, stem cells, regeneration, inflammatory bowel disease, colorectal cancer | |||||
| Jabbari | Hosna | University of Victoria | Computer Science | jabbari@uvic.ca | https://onlineacademiccommunity.uvic.ca/cobra/ | Our main goal is to help diagnose and cure human diseases by developing novel diagnostics and RNA therapeutics through research using techniques from bioinformatics, machine learning, data science and computational genomics. We are currently focusing on understanding changes in RNA structure-function during aging and disease progression. | RNA secondary structure, Structure-Function, Pseudoknot, RNA-RNA interaction, RNA-Protein interaction | https://pubmed.ncbi.nlm.nih.gov/29868872/ | https://pubmed.ncbi.nlm.nih.gov/24884954/ | |||
| Belmonte | Mark | University of Manitoba | Biological Sciences | mark.belmonte@umanitoba.ca | belmontelab.com | The Belmonte Lab at the University of Manitoba is interested in using RNA technology to drive innovation. Specifically, we use RNA technology to promote and protect some of the world's most important cropping systems. | RNA, RNAi, transcriptomics | 29743510 | 23319655 | |||
| Alain | Tommy | University of Ottawa | Biochemistry, Microbiology and Immunology | CHEO Research Institute | tommy@arc.cheo.ca | https://med.uottawa.ca/bmi/en/people/alain-tommy | mRNA translation, virology, biochemistry | RNAseq, polysome and ribosome profiling, cloning, reporter assays, western blots, viral assays, reverse genetics, oncolysis | 31851930 | 32757266 | none | |
| Holcik | Martin | Carleton University | Health Sciences | martinholcik@cunet.carleton.ca | https://carleton.ca/healthsciences/people/martin-holcik/ | Closely regulated mRNA translation (protein synthesis) plays a central role in many fundamental biological processes. Conversely, dysregulated translation has been implicated in disease pathogenesis, ranging from cancer to diabetes to neurodegeneration to rare genetic disorders. Despite this, the basic mechanistic underpinnings regulating gene expression at the post-transcriptional level are still not completely understood. We study the link between protein synthesis and disease. | mRNA translation, RNA-binding proteins, tRNA, Internal ribosome entry site, links between mutations in translation machinery and disease | https://pubmed.ncbi.nlm.nih.gov/26828225/ | https://pubmed.ncbi.nlm.nih.gov/25193871/ | |||
| Perkins | Theodore | University of Ottawa | Biochemistry, Microbiology and Immunology | Ottawa Hospital Research Institute | tperkins@ohri.ca | www.perkinslab.ca | The Perkins lab at uOttawa / OHRI specializes in bioinformatics and machine learning approaches to high-throughput data analysis and integration, including gene and microRNA expression analysis, biomarkers/signatures, and regulatory networks. | Bioinformatics, Machine Learning, Genomics, Epigenomics, Big Data, Integrative Analysis, Networks, Stem Cells, Cancer | https://pubmed.ncbi.nlm.nih.gov/16710449/ | https://pubmed.ncbi.nlm.nih.gov/32330456/ | Ottawa Bioinformatics Core Facility | |
| Li | Yifeng | Brock University | Department of Computer Science, Department of Biological Sciences, Centre for Biotechnology | yli2@brocku.ca | https://sites.google.com/view/yifengli | The Brock Biomedical Data Science Lab conduct research in bioinformatics, AI for aptamer drug design, machine learning, and biomedical data science. | Machine Learning, Drug Design, Bioinformatics, Chemoinformatics, Optimization | https://pubmed.ncbi.nlm.nih.gov/35860028/ | https://pubmed.ncbi.nlm.nih.gov/36228831/ | GPU servers and data storage servers. | ||
| Navon | Dina | University of the Fraser Valley | Biology | Dina.Navon@ufv.ca | https://dinanavon3.wixsite.com/navonresearch | Our research focuses on understanding how genomes, phenomes, environments, and development interact to build the vertebrate body. We explore these interactions using a variety of fish model systems (stickleback, zebrafish, and African cichlids) | evolution, development, evo/devo, plasticity, genomics, RNA-seq, ATAC-seq, comparative embryology | https://pubmed.ncbi.nlm.nih.gov/32719137/ | https://pubmed.ncbi.nlm.nih.gov/27900808/ | |||
| Xie | Jiuyong | University of Manitoba | Physiology & Pathophysiology | xiej@umanitoba.ca | http://home.cc.umanitoba.ca/%7Exiej/index.html | pre-mRNA processing, particularly alternative splicing, in biology and genetic diseases | alternative splicing, aberrant splicing, mutations, diseases, cancer, neurological disorders | https://pubmed.ncbi.nlm.nih.gov/11309619/ | https://pubmed.ncbi.nlm.nih.gov/9545224/ | |||
| Hu | Pingzhao | Western University | Biochemistry and Computer Science | Assistant Professor (Status-Only), Division of Biostatistics, University of Toronto | phu49@uwo.ca | https://phulab.org/ | I am particularly interested in developing deep learning algorithms for drug design, such as RNA Therapeutics, single cell RNA-seq and spatial transcriptomics. | Bioinformatics, Single-Cell RNA sequencing, Imaging-based spatial transcriptomics, Transcriptome-wide association studies (TWAS), Artificial intelligence, Deep learning-based drug design, Deep learning for RNA Therapeutics, Transcriptomics, Statistical Genomics, Coding and non-coding RNA biomarkers, | https://pubmed.ncbi.nlm.nih.gov/35664228/ | https://jcheminf.biomedcentral.com/articles/10.1186/s13321-022-00596-6 | GPU clusters | |
| Necakov | Aleksandar | Brock University | Biological Sciences | anecakov@brocku.ca | https://www.google.com/search?q=aleksandar+necakov&source=hp&ei=fSiiY6a7D9O10PEPs9uUoA4&iflsig=AJiK0e8AAAAAY6I2jSA6j1D0Ex4xhMquYAd91izz3vWs&ved=0ahUKEwjm7cSykYn8AhXTGjQIHbMtBeQQ4dUDCA4&uact=5&oq=aleksandar+necakov&gs_lcp=Cgdnd3Mtd2l6EAMyBQgAEIAEOhEILhCDARDHARCxAxDRAxCABDoLCC4QgwEQ1AIQsQM6EQguEIAEELEDEIMBEMcBENEDOgsIABCABBCxAxCDAToOCC4QgAQQsQMQxwEQ0QM6EQguEIAEELEDEMcBENEDENQCOggIABCABBCxAzoOCC4QxwEQsQMQ0QMQgAQ6CAguELEDEIMBOggILhCABBDUAjoICC4QgAQQsQM6CAgAELEDEIMBOgUILhCABDoOCC4QgAQQsQMQgwEQ1AI6CwguEIAEELEDEIMBOggILhDUAhCABDoLCC4QgAQQxwEQrwE6BggAEBYQHjoFCAAQhgNQAFiFE2CYFWgAcAB4AIABhwGIAYIOkgEEMTEuN5gBAKABAQ&sclient=gws-wiz | Intercellular Communication and Signal Integration Across Signaling Pathways from the Plasma Membrane to Intranuclear Transcriptional Factories. | RNA in situ hybridization, Live RNA Imaging, Cell Signaling, Notch Signaling, Transcriptional Condensates, Superresolution imaging, Live Imaging, | Spinning Disc Confocal Microscope, Superresolution Microscope | ||||
| Berman | Jason | University of Ottawa | Professor of Pediatrics | CHEO Research Institute, Attending Staff, Division of Hematology/Oncology ,President Canadian Hematology Society | jberman@cheo.on.ca | http://bermanzebrafishlab.com/wp/ | Genetic models of cancer and cancer predisposition syndromes; Xenotransplantation models of pediatric tumours for personalized cancer therapy; and Genetic models of rare diseases, all of which exploit various advantages inherent in the zebrafish model. | genomic editing and transplantation based approaches to generate innovative preclinical zebrafish models of cancer, precancerous disorders and other rare genetic diseases. | ||||
| Desaulniers | Jean-Paul | Ontario Tech University | Science | jean-paul.desaulniers@ontariotechu.ca | https://jpdesaulniers.com | I am a nucleic acid chemist who focuses on designing chemically-modified oligonucleotides for primary applications like gene silencing. I also focus on conjugating molecules to RNAs to improve photoregulation and delivery to cells. | siRNA; RNA synthesis; phosphoramidite; solid-phase RNA synthesis; circular dichroism; biophysical chemistry; photochemistry; gene-silencing; knockdown | https://pubmed.ncbi.nlm.nih.gov/36001232/ | https://pubmed.ncbi.nlm.nih.gov/31777918/ | |||
| Salmena | Leonardo | University of Toronto | Pharmacology and Toxicology | Princess Margaret Cancer Centre, Adjunct. Women's College Hospital, Adjunct. | leonardo.salmena@utoronto.ca | salmenalab.com | Our lab aims to identify microRNAs that are of consequence in cancer progression. We have developed methodological and computation tools and expertise to identify altered microRNA expression in cancer. We have also developed tools to identify microRNAs with therapeutic potential in cancer using CRISPR screening platforms | Cancer biology, phosphoinositide signalling, tumour suppressors, microRNA, CRISPR screens, mouse modelling | ||||
| Ensminger | Alexander | University of Toronto | Biochemistry | alex.ensminger@utoronto.ca | ensmingerlab.com | Bacterial modulation of CCR4-NOT mediated mRNA deadenylation and CRISPR-Cas. | CCR4-NOT, CNOT7, deadenylation, CRISPR-Cas, Bacteria | https://pubmed.ncbi.nlm.nih.gov/34132590/ | https://www.biorxiv.org/content/10.1101/2022.06.06.494580v1 | S&P pinning robot, Illumina MiniSeq | ||
| Park | Jeehye | University of Toronto | Genetics and Genome Biology | SickKids Research Institute | jeehye.park@sickkids.ca | https://lab.research.sickkids.ca/park/ | The Park Lab is interested in understanding the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) with the aim of identifying targetable pathways for therapeutic interventions. Our studies use multidisciplinary approaches including biochemistry, molecular cell biology, and Drosophila and mouse genetics | Neurodegeneration, amyotrophic lateral sclerosis, RNA binding proteins, MATR3, mouse models | https://pubmed.ncbi.nlm.nih.gov/33082323/ | https://pubmed.ncbi.nlm.nih.gov/35205163/ | none | |
| Anreiter | Ina | University of Toronto Scarborough | Biological Sciences | University of Toronto Department of Cell and Systems Biology (Graduate appointment), University of Toronto Department of Ecology and Evolutionary Biology (Graduate appointment) | ina.anreiter@utoronto.ca | https://www.utsc.utoronto.ca/labs/anreiter/ | The lab studies mechanisms that regulate gene expression underpinning the behavioural embedding of experience, and individual differences in behaviour. A particular focus of the lab lies in epitranscriptomics, the chamical modification of mRNAs, leading to differences in splicing, translation, and subcellular localization. | Behaviour, Genetics, Epigenetics, Epitranscriptomics, Gene expression, Nanopore Sequencing, Drosophila melanogaster | ||||
| Taipale | Mikko | University of Toronto | Donnelly Centre | Department of Molecular Genetics | mikko.taipale@utoronto.ca | taipalelab.org | Functional proteomics and genomics, technology development | Functional proteomics, functional genomics, technology development, induced proximity, host/pathogen interactions, rare disorders, protein/protein interactions | bioRxiv DOI: 10.1101/2022.08.15.503206 | 35016035 | ||
| Liu | Jun | University of Toronto | Molecular Genetics | jun.liu@utoronto.ca | https://www.individual.utoronto.ca/LIULAB/index.html | Bacterial non-coding small RNA | Mycobacterium tuberculosis, non-coding small RNA, RIP-seq, RIL-seq, CLIP-seq | https://academic.oup.com/nar/article/47/8/4292/5366473 | ||||
| Simmonds | Andrew | University of Alberta | Cell Biology | andrew@ualberta.ca | https://www.ualberta.ca/cellbiology/people/faculty/andrew-simmonds.html | RNA regulation of developmental processes in the embryo (Drosophila) | Drosophila melanogaster, P-bodies, TNRC6, RNA localizaiton, microscopy | https://pubmed.ncbi.nlm.nih.gov/16880270/ | https://pubmed.ncbi.nlm.nih.gov/30899273/ | Faculty lead, Cell Imaging Centre - Faculty of Medicine, University of Alberta | ||
| Yang | Guang | University of Calgary | Medical Genetics; Biochemistry and Molecular Biology | guang.yang2@ucalgary.ca | yanglaboratory.ca | we are interested in the molecular and cellular mechanisms that regulate the development of the mammalian brain and that, when perturbed, cause neurodevelopmental disorders. | neural stem cells, brain development, gene expression regulation, RNA biology | https://pubmed.ncbi.nlm.nih.gov/34107259/ | https://pubmed.ncbi.nlm.nih.gov/35830814/ | |||
| Rosonina | Emanuel | York University | Biology | rosonina@yorku.ca | rosonina.lab.yorku.ca | (1) Exploring roles for SUMO post-translational modifications in the regulation of gene expression. (2) Detailing molecular processes involved in gene activation, transcription, and reinitiation. | Transcription regulation and mechanisms, RNA polymerase II, sumoylation, ChIP-seq | https://pubmed.ncbi.nlm.nih.gov/28379052/ | https://pubmed.ncbi.nlm.nih.gov/31093693/ | |||
| Huang | Xi | University of Toronto | Department of Molecular Genetics / Developmental and Stem Cell Biology Program | xi.huang@sickkids.ca | https://lab.research.sickkids.ca/huang/ | We study ion channel function in brain cancer and develop ion channel-targeting therapeutic approaches. | brain tumor, medulloblastoma, glioblastoma, stem cell, blood-brain barrier, mechanobiology, mechanical force, ion channel, mouse, Drosophila | https://pubmed.ncbi.nlm.nih.gov/30344046/ | https://pubmed.ncbi.nlm.nih.gov/36323321/ | |||
| AbouHaidar | Mounir | University of Toronto | Cell and Systems Biology | The Hospital for Sick Children | mounir.abouhaidar@utoronto.ca | https://csb.utoronto.ca/faculty/mounir-g-abouhaidar/ | RNA viruses, Resistance to viral infections, Circular RNAs, Edible vaccines.Breast cancers | Viral resistance genes, Hep C vaccine, Circular RNAs in breast cancers. Plant produced vaccines. Transgenic plants | https://pubmed.ncbi.nlm.nih.gov/25253891/ | https://pubmed.ncbi.nlm.nih.gov/33514777/ | None | |
| Anreiter | Ina | University of Toronto Scarborough | Biological Sciences | University of Toronto Department of Cell and systems Biology and Department of Ecology and Evolutionary Biology (graduate appointments); Ontario Institute for Cancer research (visiting scientist) | ina.anreiter@utoronto.ca | https://www.utsc.utoronto.ca/labs/anreiter/ | The lab focuses on transcriptional regulation in the context of behavioural plasticity and pleiotropy. Our current focus is on mRNA modifications and their role in regulating gene expression, feeding behaviour, sleep, and neuronal function. | Drosophila melanogaster, genetics, gene regulation, mRNA modifications, behaviour | ||||
| Robertson | Janice | University of Toronto | Tanz Centre for Research in Neurodegenerative Diseases | jan.robertson@utoronto.ca | https://tanz.med.utoronto.ca/janice-robertson | We work on changes in RNA expression in ALDS/FTD using CHIP-seq, snRNAseq, ATACseq of mouse models and human autopsy tissues | ALS/FTD, TDP-43, RNA binding proteins, snRNAseq, ATACseq, BAC-TRAP | DOI: 10.3389/fnins.2022.868556 | DOI: 10.1093/brain/awab217 | We use https://www.pmgenomics.ca/pmgenomics/ | ||
| Cutter | Asher | University of Toronto | Ecology & Evolutionary Biology | asher.cutter@utoronto.ca | https://cutter.eeb.utoronto.ca | We study the genetic basis of evolutionary change. We are particularly interested heritable changes through time with causes that are at the interface of natural selection and non-adaptive evolutionary forces. Our research currently centers on 3 broad themes: Population genomics and genome evolution, the genetics and developmental biology of speciation, and evolutionary cell biology of sperm. | genome evolution, regulatory divergence, speciation, sperm biology, population genetics, experimental evolution | https://pubmed.ncbi.nlm.nih.gov/32902377/ | https://pubmed.ncbi.nlm.nih.gov/36223483/ | |||
| Sorensen | Poul | University of British Columbia | Pathology and Laboratory Medicine | British Columbia Cancer Research Institute | psor@mail.ubc.ca | https://www.bccrc.ca/dept/mo/labs/sorensen-lab | We are interested translational regulation of stress responses and metastatic capacity, and we are focused mainly on high-risk childhood cancers including sarcomas and CNS tumors for these studies. We are also working on identification of surface targets in high-risk childhood cancers for immunotherapy approaches. | childhood cancers; mRNA translational control; polysome profiling; proteomics; molecular pathology; stress responses; RNA binding proteins (YB-1; G3BP1/2; UBAP2L) | https://pubmed.ncbi.nlm.nih.gov/34021002/ | https://pubmed.ncbi.nlm.nih.gov/23706743/ | proteomics; polysome profiling; RNAseq; molecular pathology; cell biology | |
| LI | BOWEN | University of Toronto | PHARMACEUTICAL SCIENCES | Affiliated Scientist, Princess Margaret Cancer Centre | bw.li@utoronto.ca | www.li-bowen.com | At the University of Toronto, we harness the power of biomaterials to construct advanced delivery nanoplatforms, fueling transformative research and enabling early-stage translation of RNA medicines and gene editing tools for vaccines, immunotherapy and regenerative medicine.Our research approach is highly interdisciplinary, blending expertise from molecular bioengineering, materials chemistry, pharmaceutical sciences, molecular genetics, immunology, synthetic biology, and data sciences. Utilizing state-of-the-art technology platforms such as AI-driven design of experiments, robotic self-driving lab, organ-on-a-chip systems, and precision medicine, we are accelerating the development of innovative delivery vehicles for engineered, bespoke RNA cargos including mRNA, circRNA, siRNA, ADAR, and CRISPR-Cas9. | mRNA vaccines, lipid nanoparticles, gene editing, gene delivery | https://www.li-bowen.com/publications | |||
| Turcotte | Marcel | University of Ottawa | School of Electrical Engineering and Computer Science (EECS) | Marcel.Turcotte@uottawa.ca | https://turcotte.xyz | Our group applies machine learning, algorithm design, and efficient data structures to solve complex problems such as identifying cell type-specific DNA signatures of transcription factor binding, classifying non-coding RNA sequences, and determining RNA virus-host susceptibility. | RNA structure; RNA function; machine learning; bioinformatics; RNA-RNA interactions | 34633933 33588754 | Our group uses the resources of the Digital Research Alliance of Canada (formerly Compute Canada) | |||
| He | Housheng | University of Toronto | Medical Biophysics | Princess Margaret Cancer Centre, University Health Network, | hansenhe@uhnresearch.ca | hansenhelab.org | My lab utilizes a variety of experimental and computational genomic and epigenomic approaches to understand the functional of noncoding RNAs in Cancer development and progression | noncoding RNA, RNA modification, RNA splicing, Cancer Epigenetics and Epitranscriptomics | https://pubmed.ncbi.nlm.nih.gov/30735634/ | https://pubmed.ncbi.nlm.nih.gov/30033362/ | RNA Medicine core at Princess Margaret Cancer Centre | |
| Wong | Judy | University of British Columbia | Faculty of Pharmaceutical Sciences | Department of Medical Genetics | judy.wong@ubc.ca | https://pharmsci.ubc.ca/directory/judy-wong | My research is focused on the different mechanisms responsible for the gross structural maintenance of the genome. I have investigated the role of telomeres and telomerase in preventing chromosome erosion, and their interactions with cellular pathways that respond to DNA damage. I am also interested in three-dimensional DNA and RNA folding and how these structures affect biological control of gene expression. G-quadruplexes (G4) are guanine-rich nucleic-acid sequences capable of forming non-Watson-Crick four-strand structures. My laboratory developed new tools to visualize and to map the genomic and transcriptomic landscapes of these alternate nucleic acid structures with aims to advance the development of novel G4 binding agents for therapeutic applications. | telomere, telomerase, G-quadruplex, dyskerin, pseudouridine | Yang SY, Chang EYC, Lim JJY, Kwan H, Monchaud D, Yip S, Stirling PC and Wong JMY. G-quadruplexes mark Alternative Lengthening-of-Telomeres (ALT) human cancers. NAR Cancer 3(3) doi.org/10.1093/narcan/zcab031 (2021). | Yang SY, Monchaud D and Wong JMY. Global Mapping of RNA G-quadruplexes (G4-RNAs) using G4RP-seq. Nat Protoc 17(3):870-889. doi: 10.1038/s41596-021-00671-6 (2022). | Zeiss LSM900 Airyscan | |
| Sarah | Poynter | Wilfred Laurier University | Health Sciences | spoynter@wlu.ca | https://www.wlu.ca/academics/faculties/faculty-of-science/faculty-profiles/sarah-poynter/index.html | Nanoparticle delivery of immunostimulatory nucleic acids, for anticancer therapeutics and tools for understanding innate immune pathways. | dsRNA, toll-like receptors, fluorescence microscopy, cell biology, molecular biology | https://pubmed.ncbi.nlm.nih.gov/29740439/ | ||||
| Brown | Carolyn | University of British Columbia | Medical Genetics | carolyn.brown@ubc.ca | https://medgen.med.ubc.ca/carolyn-brown/; https://inactivexlab.com/ | Our lab studies X-chromosome inactivation, the epigenetic silencing of all but one X chromosome early in development to achieve dosage compensation between XX and XY cells. This process is initiated by the long non-coding RNA XIST, and the ability of some genes to escape the silencing underlies many sex differences in transcription. | X-chromosome inactivation, XIST, RNA FISH, heterochromatin, DNA methylation, allelic expression, escape from silencing | https://pubmed.ncbi.nlm.nih.gov/35120578/ | https://pubmed.ncbi.nlm.nih.gov/29401310/ | Q48 pyrosequencing | ||
| Reimand | Juri | University of Toronto | Department of Molecular Genetics / Computational Biology Program | Ontario Institute for Cancer Research | juri.reimand@utoronto.ca | www.reimandlab.org | We work on computational biology and cancer research, with interests in the non-coding genome, multi-omics data integration, and discovery of disease genes and biomarkers. | computational biology, multi-omics, cancer research, machine learning, pathway analysis, biomarkers | ||||
| Keffer-Wilkes | Laura | University of Lethbridge | Chemistry & Biochemistry | Director of SynBridge, iGEM Coordinator | kefferwilkesl@uleth.ca | https://www.ulethbridge.ca/core-facilities/synthetic-biology | I am interested in using synthetic biology and the iGEM program as an entry-point into biotechnology for high school students and community members. I have a love for RNA and a background in enzyme kinetics. | Synthetic biology, molecular biology, genetic engineering, outreach | https://doi.org/10.1073/pnas.160751211 | https://www.ulethbridge.ca/core-facilities/synthetic-biology | ||
| Daoud | Jamal | Galenvs Sciences Inc. | Oligo Synthesis and Purification | Industry | jdaoud@galenvs.com | www.galenvs.com | Purification processes (automated or manual) of DNA/RNA; Synthesis of Oligonucleotides (single stranded DNA and RNA); Bio-manufacturing of plasmids as controls and templates for vaccines and viral vectors | Oligonucleotides, RNA, DNA, Aptamers, Plasmids, Magnetic Nanomaterials; Enzyme Engineering; Next Generation Sequencing (NGS); Contract Research | Oligonucleotide Synthesis; Clean Room; Next Generation Sequencing (NGS) Facility; Magnetic Nanomaterial Synthesis | |||
| St-Pierre | Yves | INRS | INRS-Centre Armand-Frappier | Adjunct professor, Laval University | yves.st-pierre@inrs.ca | https://inrs.ca/en/research/professors/yves-st-pierre/ | My group has been developing novel molecular biomarkers and therapeutics for the treatment of cancer using various immunological and molecular approaches. Over the last 10 years, his group has also been conducting research on the impact of climate change on marine ecosystems using novel omics-based technology platforms that are commonly used in oncology. | Cancer, marine biology, immuno-oncology, liquid biopsy, transcriptomics, glycomics, microbiome, virome, | https://pubmed.ncbi.nlm.nih.gov/20382700/ | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223525 | ||
| Majewski | Jacek | McGill University | Human Genetics | jacek.majewski@mcgill.ca | https://majewskilab.github.io | Epigenetics of cancer and development. Regulation of transcription. Regulation of mRNA processing. Interdependence of molecular processes. | Genomics, bioinformatics, epigenetics, splicing, cancer, disease, development. | https://pubmed.ncbi.nlm.nih.gov/18193047/ | https://pubmed.ncbi.nlm.nih.gov/35593225/ | RNA-seq, ChIP-seq | ||
| Kour | Guneet | Providence Therapeutics | mRNA sciences | patrick.farrell@providencetherapeutics.com | https://providencetherapeutics.com/ | mRNA vaccine production | mRNA vaccine production, mRNA purification, in vivo and in vitro studies | |||||
| Martin Orozco | Natalia | Providence Therapeutics Holdings, Inc | R&D | natalia@providencetherapeutics.com | https://providencetherapeutics.com/ | The R&D department at Providence is interested in developing mRNA vaccines for cancer and infectious diseases. We do discovery of new targets and create candidate mRNA molecules that are evaluated for further development into a Phase 1 trial. We have access to an LNP library that allow us to use the best delivery system for each particular indication. | mRNA, LNPs, Immunotherapy, Cancer, infectious diseases, Phase 1 trials, Delivery systems, T cells, Targeting | https://pubmed.ncbi.nlm.nih.gov/35044832/ | https://pubmed.ncbi.nlm.nih.gov/19879162/ | mRNA production, LNP manufacturing, Drug discovery, drug development | ||
| Aghamohseni | Hengameh | Providence Therapeutics | Process Validation | University of Waterloo Alumni - Post Doctorate and PhD in chemical-engineering (Bioprocess) | hengameh.aghamosheni@providencetherapeutics.com | https://providencetherapeutics.com/ | Cancer, Rabies | Bioprocess, Process Validation | https://pubmed.ncbi.nlm.nih.gov/28285402/ | https://pubmed.ncbi.nlm.nih.gov/25014402/ | ||
| Gray | Michael | Dalhousie University | Biochemistry & Molecular Biology | Institute for Comparative Genomics | m.w.gray@dal.ca | https://medicine.dal.ca/departments/department-sites/biochemistry-molecular-biology/our-people/faculty/gray.html | Ribosome structure, function and evolution; RNA editing; mitochondrial and mitochondrial genome origin, evolution and function; protist genomics | ribosome; ribosomal RNA; transfer RNA; RNA editing; mitochondrial RNA | PMID: 31953324 | PMID: 33091122 | None | |
| Wilson | Joyce | University of Saskatchewan | Biochemistry, Microbiology and Immunology | joyce.wilson@usask.ca | https://medicine.usask.ca/profiles/biochemistry-microbiology-immunology/joyce-wilson.php | Our lab studies + strand RNA viruses and their interactions with host cells. We focus on the study of flaviviruses and Coronaviruses and identify host factors that promote and inhibit virus replication. We also analyse interactions between viral RNA genomes and host RNAs and how RNA genome structures regulate virus life cycles. | virus-host interactions, virus reverse genetics, miRNAs and viruses, CRISPR screens, RNA structure and function | https://pubmed.ncbi.nlm.nih.gov/34908444/ | https://pubmed.ncbi.nlm.nih.gov/30053137/ | |||
| Khan | Omar | University of Toronto | Institute of Biomedical Engineering and Department of Immunology | . | www.ofklab.com | Treating and preventing diseases using nanotechnology and nucleic acids. We design delivery systems and nucleic acid payloads for diseases-specific applications. Because of applied sciences approach, we actively perform academic research and industry product development. | Total organic synthesis, colloids, nucleic acids, engineering, optimization | https://pubmed.ncbi.nlm.nih.gov/36652629/ | https://pubmed.ncbi.nlm.nih.gov/36377494/ | |||
| Alameh | Mohamad-Gabriel | University of Pennsylvania | Pathology and Laboratory Medicine | Children Hospital of Philadelphia (CHOP) | mg.alameh@pennmedicine.upenn.edu | coming soon | My scientific research is at the interface of nanotechnology, material science, engineering, and medicine with a goal to develop prophylactic and therapeutic nucleic acid-based delivery platforms, as well as optimize their manufacturing. My research program encompass the design, study, and model structure-activity relationships for improved lipid nanoparticle (LNP) therapeutics, and nucleic acid-based vaccines. My laboratory focuses on dissecting the effect of different structural and physicochemical features of LNPs and other materials, and helper lipids on the performance, stability, and toxicity and the development of mucosal vaccines for the prevention and treatment of enteric pathogens. The goal of the Alameh research program is to develop a highly interdisciplinary, and collaborative environment that encompasses both fundamental and application-oriented projects. The research program will also address the design and manufacturing of the mRNA (broadly RNA) payloads, and the optimization of mRNA-LNP manufacturing processes. | mRNA, RNA therapeutics, mRNA vaccines, lipid nanoparticles, delivery systems, optimization, DOE | ||||
| Nechanitzky | Robert | Providence Therapeutics | Research and Development | Robert.Nechanitzky@providencetherapeutics.com | https://providencetherapeutics.com/ | We aim to harness mRNA technologies to fight cancer. | mRNA vaccination, anti-cancer drugs, adaptive and innate immune responses | https://pubmed.ncbi.nlm.nih.gov/23812095/ | https://pubmed.ncbi.nlm.nih.gov/36528755/ | mRNA-based vaccines | ||
| Popova | Petya | University of British Columbia | School of biomedical engineering | anna.blakney@msl.ubc.ca | https://blakneylab.msl.ubc.ca/ | saRNA, mRNA, nanoparticles, vaccine, protein replacement therapies, immune engineering | mRNA, saRNA, immune responses, LNPs, chronic diseases, infectious diseases | |||||
| Brown | Carolyn | University of British Columbia | Medical Genetics | carolyn.brown@ubc.ca | https://inactivexlab.com/research-2/ | We study the process of X-chromosome inactivation, the epigenetic silencing of the second X chromosome. We study how the long non-coding RNA XIST initiates the process, and how a quarter of X-linked genes manage to (partially) avoid this silencing. | Transgenes, mouse embryonic stem cells, DNA methylation, CRISPR-mediated deletions, RNA FISH, histone modifications | 1985261 | 33750950 | Q48 pyrosequencer for allelic analysis | ||
| Lu | Xiaocen | Simon Fraser University | Molecular Biology and Biochemistry | punrau@sfu.ca | https://www.rnabiochemistry.com | OUR RESEARCH GROUP STUDIES THE CHEMICAL AND BIOLOGICAL PROPERTIES OF RNA. | RNA tools, RNA biology, RNA world | https://doi.org/10.1039/D3CS00030C | https://doi.org/10.1039/D1SC01059J |